Collagen-I is thought to be the main component of the extracellular matrix in cardiac fibrosis, the accumulation of which occurs with excessive activation of matrix metalloproteinase-2 (MMP-2). MMP-2 degrades the extracellular matrix; however, the relative importance of MMP-2 to collagen-I synthesis in cardiac fibroblasts remains unclear. We investigated whether extracellular activation of MMP-...

In this paper, we study limit cycle bifurcations for planar piecewise smooth near-Hamiltonian systems with nth-order polynomial perturbation. The linear differential two centers formed in ways, one is that a center-fold point at the origin, other origin and another unique center exists. We first explore expression of order Melnikov function. Then by using function method, give estimations numbe...

In this note we study the problem of simultaneous stabilization for the algebra AR(D). Invertible pairs (fj , gj), j = 1, . . . , n, in a commutative unital algebra are called simultaneously stabilizable if there exists a pair (α, β) of elements such that αfj + βgj is invertible in this algebra for j = 1, . . . , n. For n = 2, the simultaneous stabilization problem admits a positive solution fo...

BACKGROUND One of the bottlenecks in production of biochemicals and pharmaceuticals in Saccharomyces cerevisiae is stable and homogeneous expression of pathway genes. Integration of genes into the genome of the production organism is often a preferred option when compared to expression from episomal vectors. Existing approaches for achieving stable simultaneous genome integrations of multiple D...

Objective(s): The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, whic...

MDM2 and MDM4, a structurally related MDM2 homolog, negatively regulates expression and functions of TP53 tumor suppressor gene. To explore the precise expression patterns and function of MDM2 and MDM4 in wild-type (wt) TP53 cancer cells, we analyzed 11 various cancer cell lines with wt TP53. All cell lines exhibited deregulated expression of MDM2 and MDM4, and were divided into two distinct ty...

a spectrophotometric method for selective complexation reaction and simultaneous determination of mycophenolate mofetil (mpm), and mycophenolic acid (mpa) using three multivariate chemometric methods, i.e. partial least squares regression, principal component regression and principal component artificial neural networks, is proposed. the method is based on the complexation reaction of mpm and m...