A novel stability-indicating reverse phase high performance liquid chromatography method was developed and validated for the simultaneous determination of Celecoxib (CEL) and Diacerein (DIN) and its impurities in capsule dosage form. The method was developed using L1 column with gradient using the mobile phase consist of Solution A (pH = 2.3 buffer) and Solution B (methanol and acetonitrile; 50...

A thorough, systematic study into the effect that structurally related impurities have on both process and product quality during crystallization of an active pharmaceutical ingredient is presented. The presence acetanilide metacetamol influences paracetamol. Where high concentrations either impurity were present in feed, recovery decreased by up to 15%. Acetanilide included final through adsor...

In this study, a simple, selective, and accurate analysis method was developed for the simultaneous determination of anti-inflammatory drugs (paracetamol diclofenac) existing inlet outlet wastewater treatment system. This used solid-phase extraction (SPE) reversed-phase high-performance liquid chromatography with photodiode array detector (HPLC-PDA). Separation performed using an HSR C18 column...

A simple and highly sensitive spectrophotometric method for the determination of paracetamol has been developed. The employed methodology involves reaction of paracetamol with iron(III) and subsequent reaction with ferricyanide in acid medium, which yield a Prussian blue product with maximum absorption at 730 nm. Beer’s law was obeyed for the paracetamol concentration range from 0.20-3.00 g ml...

While HPLC has traditionally been the method of choice for purity determination of pharmaceutical substances, capillary electrophoresis (CE) offers a different selectivity and hence it is a complementary technique to HPLC. Loratadine, an antihistamine, could include in its raw material seven impurities that ought to be separated, identified and quantified for drug development and quality contro...