An ethnically Chinese patient with newly diagnosed metastatic gastro-intestinal stromal tumour initially treated with imatinib mesylate developed severe interstitial lung disease. As his condition improved after cessation of imatinib mesylate and treatment with corticosteroids, he was started on sunitinib malate. His clinical course was then unfortunately complicated with intra-tumour bleeding....

Meckel's diverticulum is the most common congenital anomaly of the gastro-intestinal tract. It arises as a result of incomplete dissolution of the vitello-intestinal duct. Approximately 4% of patients with Meckel's diverticula develop complications, most commonly obstruction, gastro-intestinal bleeding and inflammation. We describe three unusual presentations of Meckel's diverticulum-perforatio...

Primary aorto-duodenal fistula is a rare and life-threatening cause of upper gastro-intestinal bleed. In this case report, a patient presented acutely with several episodes of haematochezia and pulseless lower limbs bilaterally. Primary aorto-duodenal fistula with peripheral vascular disease was diagnosed after an urgent CT angiogram was performed. She underwent left axillo-bifemoral bypass, re...

A 26-year-old woman was regularly followed up in a gastro-intestinal out-patient clinic. Since early childhood, she was noted to have hyperpigmented lesions over the perioral region (Fig 1a) and fingers (Fig 1b), and a history of small intestinal intussusception due to polyps that was treated by surgery when she was 12 years old. Endoscopic assessment revealed multiple gastric polyps (Fig 1c) a...

Over several centuries, oral dosage forms have remained incomparably superior to alternative medication delivery methods. For its ease of formulation and administration, stability, excellent rate patient compliance, the route is preferred. Gastric emptying has been a major drawback for drugs that stay very short period in stomach. An innovative method gastro-intestinal retention allows form gas...

To date, most concepts on the frequency of gastro-oesophageal reflux episodes and the efficiency of the antireflux barrier have been based on inferences derived from measurement of oesophageal pH. The development of intraluminal impedance monitoring has highlighted the fact that pH monitoring does not detect all gastro-oesophageal reflux events when little or no acid is present in the refluxate...

M.D. (Pp. xii + 566; figs. 415. 144s.) London: Bailliere, Tindall & Cox, 1958. THIS work covers every conceivable aspect of obstruction in the gastro-intestinal tract from the cesophagus to the anal canal in a truly encycloprdic manner. The book contains a tremendous amount of information and approximately 1,700 references in the bibliography. It is refreshing here to note that the authors incl...

Professor of Greek tells me that he truly believes the classics have made him what he is. This is a very grave statement, if well founded. Indeed, I have heard the same argument from a great many Latin and Greek scholars. They all claim, with some heat, that Latin and Greek have practically made them what they are. This damaging charge against the classics should not be too readily accepted. In...

Gastro-esophageal reflux (GER) is a physiological phenomenon occurring in every individual. Gastro-esophageal reflux Disease (GERD) is a pathological condition where the reflux into the esophagus causes local changes and aspiration of the gastric contents in to the lungs can cause serious, even life threatening conditions. GERD is common but under-diagnosed condition in children. There are fund...