Silymarin (SL), a mixture of flavonolignans mainly including silybin A and B, isosilybin A and B, silidianin, and silychristine from the seeds of Silybum marianum L., has been widely used to treat acute and chronic viral hepatitis, toxin/drug-induced hepatitis, cirrhosis, alcoholic fatty liver diseases and other ailments because of its excellent hepatoprotective effect. Silybin is the most acti...

Retinoic acid (RA) has been effective for improving wrinkles. However, it has also been reported that RA induces skin irritation. In this study, we explored new botanical compounds that show RA-like activity, but do not induce inflammation in vitro. Keratinocytes were maintained in a confluent condition and induced differentiation. Under this condition keratinocytes were treated with many botan...

This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin. Silymarin and silybin used so far mostly as hepatoprotectants were shown to have other interesting activities as e.g., anticancer and canceroprotective. These acti...

Silymarin and its flavonolignan isomers, silybin, isosilybin, dehydrosilybin, silychristin, silydianin, and a few flavonoids mainly taxifolin, have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for silymarin and active seed extracts of Silybum marianum against different bacteria, fungi, viruses and pa...

The medicinal plants are of great use in pharmaceutical, cosmetic, agricultural and food industry. The efficacy of some herbal products is beyond doubt, the most recent examples being Silybum marianum (Linn.) Gaertn (Silymarin), Artemisia annua Linn. (Artemesinin) and Taxus baccata Linn.(taxol). Randomized, controlled trials have proved the efficacy of some established remedies, for instance Zi...

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymar...

Silybin A (1), silybin B (2), and isosilybin A (3), three of the seven flavonolignans that constitute silymarin, an extract of the fruits of milk thistle (Silybum marianum), were detected for the first time from a fungal endophyte, Aspergillus iizukae, isolated from the surface-sterilized leaves of S. marianum. The flavonolignans were identified using a UPLC-PDA-HRMS-MS/MS method by matching re...

background and objectives: milk thistle (silybum marianum), a medicinal plant of the asteraceae family that have been used long time ago, in the treatment of liver disease. sowing date of this plant has not been determined, therefore, this study was necessary. this plant was identified as a weed, this plant is identified as a weed, while silymarin in the seeds are used in the anti-hepatitis and...

Silymarin (standardized extract from the seeds of the Silybum marianum) has been used in the supportive therapy of liver diseases and its cytoprotective activity is believed to be based on antioxidant properties. Our previous works showed hypolipidemic effects of silymarin. The ATP-binding cassette (ABC) transporters G5 and G8 play a major role in biliary cholesterol secretion. The ABCA1 transp...

Silymarin, an extract from Silybum marianum, has been shown to have antioxidant properties. However, there is no scientific report on wound healing activity of the silymarin. The purpose of this study was to evaluate the effect of topical administration of silymarin on excision wound healing in rats. Excision wounds were made on the back of rats. Rats were divided into three groups, as control,...