The role of neo-angiogenesis in prostate cancer (PCA) growth and metastasis is well established, but the development of effective and non-toxic pharmacological inhibitors of angiogenesis remains an unaccomplished goal. In this regard, targeting aberrant angiogenesis through non-toxic phytochemicals could be an attractive angiopreventive strategy against PCA. The rationale of the present study w...

Hepatitis viral infection is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Over one million people are estimated to be persistently infected with hepatitis C virus (HCV) worldwide. As capsid core protein is the key element in spreading HCV; hence, it is considered to be the superlative target of antiviral compounds. Novel drug inhibitors of HCV are in need...

Curcumin has been traditionally used in food recipes for biological health benefits. However, these properties are compromised due to its very low bioavailability. Thus, this work assessed the impact of using natural potential bioenhancers improve intestinal permeability and understanding interaction flavonoids with curcuminoids through molecular dynamic simulation. The (Papp) was measured on h...

Extremophilic biocatalysts represent an enhanced solution in various industrial applications. Integrating enzymes with high catalytic potential at low temperatures into production schemes such as cold-pressed silymarin processing not only brings value to the recovery from biomass residues, but also improves its solubility properties for biocatalytic modification. Therefore, a cold-active lipase...

milk thistle is used traditionally as a hepaprotective agent and supportive treatment of liver disorders. the most problems in milk thistle harvest are tall height, seed shedding and being spinous. in this trial, effects of 3 native populations (p1: isfahan violet flower, p 2: ahvaz white flower and p3: ahvaz violet flower) and 3 topping levels (t1:control, t2: topping in 7 leaves stage and t3:...

Anchusa strigosa L.: Hardy annual biennial or perennial herb, with hairs especially on the leaves., flowers generally regular. Commonly named (Lisan Althour) in Iraq, from Boraginaceae family. The plant contains phenolic acids, flavonoids, alkaloids, sterols, and terpenoids. Whole part defatted n-hexane for 24 hours. material extracted using absolute methanol by Soxhlet apparatus hours, extract...