The use of silencers to reduce noise is mandatory due severe hearing damage caused by high venting in the engine room ocean-going vessels. While straight and perforated tubes have been used as acoustical elements traditional silencer design, studies shown that design still requires improvement. To enhance efficiency, multi-chamber mufflers proposed composed screw tubes. Additionally, a mathemat...

Simply put, the term “mobile phone silencer” is a generic one that describes a class of devices that disrupt mobile phone service. Their purpose is to create a “silent zone,” in which normal cell coverage is interfered with and in which mobile phones cannot operate. This, supposedly, enforces phone etiquette in places where ring tones and phone conversations are unacceptable or forbidden. Some ...

Increased levels of the repressor element 1/neuron restrictive silencer element (RE1/NRSE) silencing activity promoter, and a consequent reduction in the transcription of many RE1/NRSE-bearing neuronal genes, including brain-derived neurotrophic factor (BDNF), have been demonstrated in Huntington disease (HD) and represent one possible effector of its selective neuronal vulnerability. Restoring...

Antisense oligonucleotides (ASOs) can be used to alter the splicing of a gene and either restore production of a required protein or eliminate a toxic product. In this issue of Genes & Development, Hua and colleagues (pp. 1634-1644) show that ASOs directed against an intron splice silencer (ISS) in the survival motor neuron 2 (SMN2) gene alter the amount of full-length SMN transcript in the ner...

Stampidine as a Potent Epigenetic Silencer of Host HIV Dependency Factor Genes in HIV-Infected Cells Sanjive Qazi1,2,3 and Fatih Uckun2,3,4* 1Bioinformatics Program, Department of Biology, Gustavus Adolphus College, St. Peter, MN, USA 2Department of Virology and Drug Discovery Program, Parker Hughes Institute, St. Paul, MN 55455, USA 3Developmental Therapeutics Program, Children’s Hospital Los ...