Background: Hepsin, a type II transmembrane serine protease encoded by HPN gene, is commonly overexpressed in prostate and breast cancer. Hepsin protein stabilized Ras-MAPK pathway signaling, downstream, this regulates the degradation of extracellular matrix components activates growth factor pathways, including hepatocyte transforming (TGF) beta pathway. The significance hepsin-dependent signa...

Neuroinflammatory disorders include a wide spectrum of disorders in which immune system injures components of the nervous system. Despite the advances in therapy, lack of efficient curative therapies for these disorders not only affects the quality of life but also places huge burden on the society. These limitations have necessitated therapeutic interventions for developing more efficient regi...