Natural selection is an important factor influencing variation in the human genome, but most genetic studies of natural selection have focused on variants with unknown phenotypic associations. This trend is changing. New studies are rapidly revealing the effects of natural selection on genetic variants of known or likely functional importance.

In this paper we prove the existence of an optimal set for minimization kth variational eigenvalue p-Laplacian among p-quasi open sets fixed measure included in a box finite measure. An analogous result is obtained eigenvalues associated with Schrödinger potentials. order to deal these nonlinear shape optimization problems, develop general approach which allows treat continuous dependence sign-...

BACKGROUND Transverse sinus stenosis (TSS) is common among patients with cerebral venous sinus thrombosis. No previous studies have reported on double-track sign detected on axial Gd-enhanced T1WI in TSS. This study aimed to determine the sensitivity and specificity of the double-track sign in the detection of TSS. METHODS We retrospectively reviewed medical records of 383 patients with trans...

Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is a type II C-type lectin that functions as an adhesion receptor and mediates binding and internalization of pathogens such as virus (human immunodeficiency virus, hepatitis C), bacteria (Mycobacterium), fungi, and parasites. DC-SIGN expression in vivo is primarily restricted to interstitial dendritic cells (DC) and certain tissue m...

Dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is a DC-specific C-type lectin that plays an important role in recognizing and capturing pathogens, DC migration and initiation of T cell responses. Here, we show that anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb), originally prepared for blockade of the adhesive molecule P-selecti...

Background: Herpes simplex virus type 2 (HSV-2) seroprevalence has been shown to be a potential sign of infection in pregnant women, and it could be applied to check HSV-2 transmission. This study evaluated the anti-HSV-2 IgG prevalence in pregnant women who were referred to health centers in Urmia, Northwest of Iran, during 2014-2015. Methods: Serum samples were collected from 86 pregnant wome...

data envelopment analysis (dea) has been proven as an efficient technique to evaluate the performance of homogeneous decision making units (dmus) where multiple inputs and outputs exist. in the conventional applications of dea, the data are considered as specific numerical values with explicit designation of being an input or output. however, the observed values of the data are sometimes imprec...

This paper describes a tool that combines features found in empirical sign language lexicography and in sign language discourse transcription. It supports the user in lexicon building while working on the transcription of a corpus. While it tries to reach a certain level of compatibility with upcoming multimedia annotation tools, it offers a number of unique features considered essential due to...

QCD in the ε-regime at nonzero baryon chemical potential µ is reviewed. The focus is on aspects of the sign problem which are relevant for lattice QCD. It is discussed how spontaneous chiral symmetry breaking and the sign problem are related through the spectrum of the Dirac operator. The strength of the sign problem is linked to the quark mass and the chemical potential. Specific implications ...