A side-effect analysis computes for each program phrase a set of memory locations that may be read or written to when executing this phrase. Our analysis expresses abstract objects, points-to and aliasing information, escape information, and side effects all in terms of a single novel abstract domain, generalized access graphs. This abstract domain represents sets of access paths precisely and ...

A 47 year old patient has been treated for psychotic depression for the last 5 years. The illness began manifesting through the symptoms of depressive thoughts, intrapsychic tension, projectivity, derealisation phenomena and pre-psychotic fears. She was treated with a combination of antidepressives, anxiolitics and hypnotics in ambulatory conditions. The therapy applied did not obtain the effec...

RATIONALE Regorafenib represents a treatment option in heavily pretreated patients affected by metastatic colorectal cancer (mCRC). Its safety profile is typical of small-molecule tyrosine-kinase inhibitors (TKIs) and most adverse events are manageable. PATIENT CONCERNS A 56 years-old Caucasian man affected by mCRC with normal hepatic reserve was treated with regorafenib as second-line treatm...

A view is an un-instantiated relation. The contents of its instance depend on the view query and the instances of the base tables. For that reason, an update issued on the view cannot be directly applied on the view instance. Instead, it has to be translated into a series of updates on the base tables so that when the view query is applied again on the modified base table instances, the result ...