Homozygous sickle cell disease in the eastern province of Saudi Arabia is clinically mild. Circulating fetal hemoglobin levels of 16.0 +/- 7.4% were found in these anemic patients, but only 1.09 +/- 0.97% in their sickle trait parents. To determine whether these sickle cell anemia patients inherit an increased capacity to synthesize fetal hemoglobin, a radioimmunoassay of fetal and adult hemogl...

Background: Sickle cell trait, the heterozygous state for sickle disorders (SCD), which is associated with various obstetrical and non- complication. Our objective was to study pregnancy outcome in women trait.Methods: A prospective observational conducted collecting data from medical records of around 40 consecutive consenting subjects admitted a tertiary health care center south Gujarat over ...

1Central Department of Maternal and Child Health, Ministry of Health, Abu-Dhabi, United Arab Emirates. 2Department of Haematology, Central and Al Jazira Hospitals, Abu-Dhabi, United Arab Emirates. Received: 10/04/03; accepted: 15/03/04 ABSTRACT In January 2002, a pilot programme of neonatal screening for sickle cell disease was launched in the United Arab Emirates (UAE) in 3 districts of Abu Dh...

Routine hematological tests were performed in a family which was at risk for sickle cell disease. Cellulose acetate electrophoresis and Triton PAGE were employed to differentiate between various variants of hemoglobin. Based on the data a pedigree was constructed which indicated that few members of the respectively had received the S gene, some of them were sickle cell disease while few were si...

Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepat...

This study aimed to to determine the prevalence of Sickle cell diseases and trait and high hemoglobin (Hb) A2 βthalassemia in the province of Makkah among patients of Al-Noor Specialist hospital, Makkah. Retrospective studying the results of 620 requested saudi patients (256 male and 364 female) suffer from Anemia for gel electrophoresis. Covering the period between 1 January 2012 to 30 Decembe...

The frequent occurrence of hyposthenuria in patients with sickle cell anemia has been noted since 1928 (1). McCrory, Goren, and Cornfeld (2), and Kunz, Pratt, Mellin, and Cheung (3), established that the urinary concentration defect was not due to a deficiency of the antidiuretic hormone and Zarafonetis, Steiger, Molthan, McMaster, and Colville (4), reported that subjects with the sickle cell t...