The termination of activation signals is a critical step in the control of the immune response; perturbation of inhibitory feedback pathways results in profound immune defects culminating in autoimmunity and overwhelming inflammation. FcgammaRIIB receptor is a well described inhibitory receptor. The ligation of B-cell receptor (BCR) and FcgammaRIIB leads to the inhibition of B-cell activation. ...

We report about a hierarchical design for extracting ship features and recognizing ships from SAR images, and which will eventually feed a multisensor data fusion system for airborne surveillance. The target is segmented from the image background using directional thresholding and region merging processes. Ship end-points are then identified through a ship centerline detection performed with a ...

We study the problem of query evaluation with the help of the crowd, when the value of the queried attributes is not available in the database and is also hard for the crowd to estimate. Rather than asking users directly about these attributes, we propose a novel alternative approach that first uses the crowd to dismantle the query attributes into finer related ones (whose value estimation is e...

In recent years a great deal of research efforts in ship hydromechanics have been devoted to practical navigation problems in moving larger ships safely into existing harbours and inland waterways and to ease congestion in existing shipping routes. The starting point of any navigational or design analysis lies in the accurate determination of the hydrodynamic forces generated on the ship hull m...

Homologous recombination is associated with the dynamic assembly and disassembly of DNA-protein complexes. Assembly of a nucleoprotein filament comprising ssDNA and the RecA homolog, Rad51, is a key step required for homology search during recombination. The budding yeast Srs2 DNA translocase is known to dismantle Rad51 filament in vitro. However, there is limited evidence to support the disman...

Ozone concentrations in the Mediterranean area regularly exceed the maximum levels set by the EU Air Quality Directive, 2008/50/CE, a maximum 8-h mean of 120 μg·m−3, in the summer, with consequences for both human health and agriculture. There are a number of reasons for this: the particular geographical and meteorological conditions in the Mediterranean play a part, as do anthropogenic ozone p...

With the rapid development of spaceborne synthetic aperture radar (SAR) and the increasing need of ship detection, research on adaptive ship detection in spaceborne SAR imagery is of great importance. Focusing on practical problems of ship detection, this paper presents a highly adaptive ship detection scheme for spaceborne SAR imagery. It is able to process a wide range of sensors, imaging mod...

In this paper, we analyze the state-of-the-art replacement policy based on Signature-Based Hit Prediction (SHiP). While we observe that the proposed SHiP implementation improves performance over the LRU policy on all configurations, we identify three areas of improvement. First, the policies for updating the counters in the Signature History Counter Table (SHCT) can be modified. Second, a broad...

BACKGROUND: The 'drip-and-ship' paradigm denotes a treatment regimen in patients in whom intravenous (IV) recombinant tissue plasminogen activator (rt-PA) is initiated at the emergency department (ED) of a community hospital, followed by transfer within 24 h to a comprehensive stroke center. Although the drip-and-ship paradigm has the potential to increase the number of patients who receive IV ...