Since 1965, the Naval Ship Engineering Center (NA VSEC) and the Naval Ship Research and Development Center (NSRDC), sponsored by the Naval Ship Systems Command, have been actively involved in developing and using computer facilities for the design and construction of naval ships. The overall goals of this effort, known as the Computer-Aided Ship Design and Construction (CASDAC) project, have be...

In this thesis, the author concentrates on marine accident frequency models and on the analytical estimation of accident frequency in the Gulf of Finland. The Gulf of Finland is a sensitive sea area and a part of Baltic Sea. Automatic Identification System (AIS) data of 2008 is used in the calculations of ship-ship collision and grounding frequency. In addition, an estimate of collision frequen...

The SH2-containing inositol phosphatase, SHIP, often appears as multiple bands in anti-SHIP immunoblots. To characterize these bands, antisera were generated against the N-terminal (anti-N), mid-region (anti-M), and C-terminal (anti-C) portions of SHIP. Immunoprecipitation and immunoblotting studies showed that 145-, 135-, 125-, and 110-kD bands were detected in lysates from the murine hematopo...

The leukemic T cell line Jurkat is deficient in protein expression of the lipid phosphatases Src homology 2 domain containing inositol polyphosphate phosphatase (SHIP) and phosphatase and tensin homolog deleted on chromosome ten (PTEN). We examined whether the lack of expression of SHIP-1 and PTEN is shared by other leukemic T cell lines and PBLs. Analysis of a range of cell lines and PBLs reve...

The Concept and Requirements Exploration process used at Virginia Tech is based on a Multi-Objective Optimization approach that explores the design space to produce a NonDominated set of ship design solutions ranked objectively by Cost, Risk, and Effectiveness. Prior research and effort has also been made to leverage the validation and verification of the U.S. Navy’s ship synthesis design tool,...

The problem of mathematical model adequacy of ship dynamics in a seaway is discussed. We have also discussed various approaches to defining mathematical model components of ship interaction with the environment, physical pictures of heeling and capsizing the ship in a seaway, specific features of the computer technology and the interpretation of results. We have given examples of numerical and ...

The platelet receptor for the von Willebrand factor (VWF) glycoprotein Ib-IX-V (GPIb-IX-V) complex mediates platelet adhesion at sites of vascular injury. The cytoplasmic tail of the GPIb subunit interacts with the actin-binding protein, filamin, anchoring the receptor in the cytoskeleton. In motile cells, the second messenger phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) induces s...

The intracellular gram-negative bacterium Francisella tularensis causes the disease tularemia and is known for its ability to subvert host immune responses. Previous work from our laboratory identified the PI3K/Akt pathway and SHIP as critical modulators of host resistance to Francisella. Here, we show that SHIP expression is strongly down-regulated in monocytes and macrophages following infect...

In line with the current research on the ultimate strength assessment of ship hull girders, careful understanding of the collapse behaviour of unstiffened plate elements within the ship hull girders is an important and necessary task. In this paper, the collapse behaviour of unstiffened plates under longitudinal and transverse thrust is studied by elastoplastic large deflection FEM and the char...