نتایج جستجو برای: sgs
تعداد نتایج: 1423 فیلتر نتایج به سال:
Myosin Va (MyoVa) is a prime candidate for controlling actin-based organelle motion in neurons and neuroendocrine cells. Its function in secretory granule (SG) trafficking was investigated in enterochromaffin cells by wide-field and total internal reflection fluorescence microscopy. The distribution of endogenous MyoVa partially overlapped with SGs and microtubules. Impairing MyoVa function by ...
هدایت هیدرولیکی اشباع خاک یکی از پارامترهای اساسی در پروژههای زهکشی است. بنابراین، شناخت الگوی توزیع مکانی هدایت هیدرولیکی ضروری است. از طرفی، دست‌یافتن به چنین اطلاعاتی نیازمند اندازهگیریهای متعدد هدایت هیدرولیکی و صرف وقت و هزینة بسیار است. انواع روشهای کریجینگ میتوانند برای برآورد و پهنهبندی هدایت هیدرولیکی خاک به کار روند. با این حال، مقادیر برآوردشده همواره با درصدی خطا همراه است. ...
Sjögren's syndrome (SjS) is an autoimmune disease characterized by distraction of particularly salivary and lacrimal glands. The aim of the present study was to compare salivary gland scintigraphy (SGS) and salivary gland ultrasonography (SUS) in identifying salivary gland function in patients first diagnosed with SjS. We recruited 20 such patients with SjS (5 male, 15 female, aged from 35 to 6...
Large eddy simulation (LES) is regarded as one of the most promising numerical methods to predict unsteady turbulent flows at high Reynolds number. In LES the flow field is decomposed into grid and subgrid scales. The grid scale (GS) flow field is computed numerically using discrete filtered Navier-Stokes equation with a model for the subgrid scale (SGS) stress. Therefore, the reliability of th...
An essential constituent of the integrated stress response (ISR) is a reversible translational suppression. This mRNA silencing occurs in distinct cytoplasmic foci called stress granules (SGs), which transiently associate with processing bodies (PBs), typically serving as mRNA decay centers. How mRNAs are protected from degradation in these structures remains elusive. We identify that Zipcode-b...
Many eukaryotes share a common response to environmental stresses. The responses include reorganization of cellular organelles and proteins. Similar stress responses between divergent species suggest that these protective mechanisms may have evolved early and been retained from the earliest eukaryotic ancestors. Many eukaryotic cells have the capacity to sequester proteins and mRNAs into transi...
Stress is a significant life event. The immediate response to stress is critical for survival. In organisms ranging from the unicellular Saccharomyces cerevisiae to protozoa (Trypanosoma brucei) and metazoan (such as Caenorhabditis elegans, Homo sapiens) stress response leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules (SGs). SGs regulate cell survival d...
Stress granules (SGs) are formed in response to stress, contain mRNAs, 40S ribosomal subunits, initiation factors, RNA-binding and signaling proteins, and promote cell survival. Our study describes a novel function of the protein heterodimer SRP9/14 and Alu RNA in SG formation and disassembly. In human cells, SRP9/14 exists assembled into SRP, bound to Alu RNA and as a free protein. SRP9/14, bu...
Predictions from conventional large-eddy simulation (LES) are known to be gridspacing and spatial-discretization-order dependent. In a previous article (Radhakrishnan & Bellan, J. Fluid Mech., vol. 697, 2012a, pp. 399–435), we reformulated LES for compressible single-phase flow by explicitly filtering the nonlinear terms in the governing equations so as to render the solution grid-spacing and d...
Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of malignancy. SGS is caused by de novo germline mutations clustering to a 12bp hotspot in exon 4 of SETBP1. Mutations in this hotspot disrupt a degron, a signal for the regulation of protein degradation, and lead to the accumulation of SET...
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