Abstract Sex bias in cancers arising from nonreproductive organs is known but poorly understood. We recently reported on a T cell-intrinsic role of androgen receptor (AR) driving CD8 +T cell exhaustion which underlies the poorer tumor control males (Kwon et al., Sci Immunol, 2022). This study aims to understand how AR regulates +tumor-infiltrating lymphocytes (TILs) by identifying its genome-wi...

A case is reported with clear cell sarcoma (CCS) of the hand. Early diagnosis of clear cell sarcoma is always difficult due to its slow growing nature, benign clinical appearance, lack of pigmentation in most cases, and relatively young age of patients which make it to clinically appear as a benign soft tissue tumor. We report a case of clear cell sarcoma of hand in a 56 year old male with a no...

Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific ant...

Background: Granular cell tumor (Abrikossoff’s tumor) is a rare and slow-growing tumor of the soft tissue. Originated from the Schwann cells, it is often a benign tumor, but it can be malignant in 1-3% of the cases. Malignant cases can cause significant morbidity and mortality. It may develop in many anatomic locations, especially in the head and neck region, and also in skin and subcutaneous t...

Adult stem cells maintain tissue homeostasis by balancing selfrenewal and differentiation. In Drosophila females, germline stem cells (GSCs) require Sex lethal (Sxl) to exit the stem cell state and to enter the differentiation pathway. Without Sxl GSCs do not differentiate and instead form tumors. Previous studies have shown that these tumors are not caused by a failure in the self-renewal/ dif...

nowadays, new advances in the use of cell free fetal dna (cffdna) in maternal plasma of pregnant women has provided the possibility of applying cffdna in prenatal diagnosis as a non-invasive method. in contrary to the risks of invasive methods that affect both mother and fetus, applying cffdna is proven to be highly effective with lower risk. one of the applications of prenatal diagnosis is fet...

breast cancer is the most common cancer in women. several risk factors such as age, family history of breast cancer, marital status, early menarche and late menopause are related to breast cancer. obesity is also a main health problem associated with breast cancer incidence and subsequent mortality. association between obesity and expansion of breast cancer may be due to excessive sex steroid h...

clear cell variant of ependymoma is almost exclusively located in the supratentorial region. only few cases of this tumor that located in the spinal cord have been reported. here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. in microscopic examination, the tumor cells were round to oval with moderate amounts of clear cytoplasm and centrally located large ...