A 12-year-old female with developmental delay/mental retardation and a family history of gynecologic cancers presented with nonspecific abdominal complaints and was found to have a 4.5-kg, 25- x 23- x 15-cm pelvic mass with solid and cystic components and associated retroperitoneal and mesenteric lymphadenopathy. Laboratory studies revealed increased serum levels of CA-125 and inhibin B. Histol...

We are providing free digital resources for teaching neuroscience labs at http://mdcune.psych.ucla.edu/. These resources will ultimately include materials for teaching laboratories in electrophysiology of neuronal circuits (SWIMMY), a Neuroinformatics/Bioinformatics module, and two modules for investigating the effects of hormones on early CNS development-one focusing on the development of the ...

The authors reported in 1972 a statistical study based on 501 cases of malignant melanoma. As continouous study this review was carried out on 456 cases of melanoma which were reported during six years between 1970 and 1976. These two studies showed quite similar results as follows: (1) Yearly incidnece of malignant melanoma indicated a definite upward trend and the average number of patients w...

Backrest position is a significant parameter in handcycling that one must consider when seeking to optimize the user-to-chair interface. We studied the effects of backrest position on handcycle propulsion kinematics. Ten nondisabled partici pants with no handcycle propulsion experience repeated an 8 s sprint with three backrest positions (backrest angle between 45 degrees and 50 degrees to the ...

Ovarian neoplasms are relatively rare in childhood and adolescence; only 5% to 8% of the cases are of sex cord stromal origin. Granulosa cell tumors are a group of estrogen producing sex cord stromal tumors of the ovary. They occur in 95% of the cases in adults, and only about 5% of the cases, which differ in histologic characteristics, are of juvenile type. A 13-year-old girl is reported who p...

Chemoradiotherapy has substantially improved life expectancy in young women with cancer, but these treatments often cause infertility. One method of preserving fertility is to cryopreserve ovarian tissue, with subsequent autotransplantation of the tissue after successful anticancer therapy. This study examined the long-term effect of heterotopic transplantation of cryopreserved ovarian tissue o...

Mild hirsutism and alopecia in postmenopausal women can be a normal physiological response. Sex cord stromal tumors of ovary account for approximately 5-8% of all ovarian tumors. When hirsutism is accompanied by signs of virilization such as severe balding, deepening of voice or clitoromegaly, an underlying androgen-secreting tumor, that may be malignant must be ruled out. We report a rare case...

The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesi...

introduction: the fetus needs a considerable amount of cholesterol for the development of tissues and organs.  studies have suggested that genetic and environmental factors influence the composition of cord blood lipoproteins.  in this study, we aim to assess the effect of gestational age, sex and birth weight on the cord blood lipoproteins. methods: we collected umbilical cord blood samples fr...

background: tumors of the central nervous system (cns) are a heterogeneous group of neoplasms with different prevalence in different sex and age groups and various parts of cns. objectives: determining the relative frequency of different types of cns tumors in different ages, sex and cns anatomical locations. materials and methods: this retrospective study was performed using pathological repor...