نتایج جستجو برای: severe oligozoospermia

تعداد نتایج: 327662  

Journal: :Reproductive biology and endocrinology : RB&E 2004
Helen G Tempest Sheryl T Homa Maria Dalakiouridou Dimitra Christopikou David Wright Xiao P Zhai Darren K Griffin

BACKGROUND The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm. The relationship between individual semen parameters and segregation of specific chromosome pairs is however less well reported as is the variation of disomy levels in indiv...

Journal: :Annales de biologie clinique 2014
Wajih Hammami Olfa Kilani Mariem Ben Khelifa Wiem Ayed Sonia Abdelhak Abderrezzak Bouzouita Fethi Zhioua Ahlem Amouri

Yq microdeletions are the leading genetic cause of male infertility and its detection in clinically relevant for appropriate genetic counseling. The objective of this study was to determine the frequency of Y microdeletion in a group of Tunisian infertile men and to compare the prevalence of these abnormalities with other countries and other Tunisian reported series. Totally, 105 Tunisian idiop...

Journal: :Human molecular genetics 1996
P H Vogt A Edelmann S Kirsch O Henegariu P Hirschmann F Kiesewetter F M Köhn W B Schill S Farah C Ramos M Hartmann W Hartschuh D Meschede H M Behre A Castel E Nieschlag W Weidner H J Gröne A Jung W Engel G Haidl

In a large collaborative screening project, 370 men with idiopathic azoospermia or severe oligozoospermia were analysed for deletions of 76 DNA loci in Yq11. In 12 individuals, we observed de novo microdeletions involving several DNA loci, while an additional patient had an inherited deletion. They were mapped to three different subregions in Yq11. One subregion coincides to the AZF region defi...

2014
Dana Mierla Dumitru Jardan Veronica Stoian

BACKGROUND Chromosomal abnormalities and Y chromosome microdeletions are regarded as two most frequent genetic causes associated with failure of spermatogenesis in the Caucasian population. MATERIALS AND METHODS To investigate the distribution of genetic defects in the Romanian population with azoospermia or severe oligozoospermia, karyotype analysis by G-banding was carried out in 850 idiopa...

2017
M. Punab O. Poolamets P. Paju V. Vihljajev K. Pomm R. Ladva P. Korrovits M. Laan

STUDY QUESTION What are the primary causes of severe male factor infertility? SUMMARY ANSWER Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. WHAT IS KNOWN ALREADY There are few large-scale epidemiological studies analyzing the causes of mal...

Journal: :iranian biomedical journal 0
حمید علیزاده نیلی hamid alizadeh nili حسین مزدرانی hossein mozdarani franck pellestor

background: various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. moreover, sperm dna damage is shown to be associated with male infertility. in this study, the rate of dna damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. methods: semen samples were obtained from healthy normal and subfertile ...

Journal: :journal of paramedical sciences 0
farhad shaveisi-zadeh department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran kimia davarian department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran abolfazl movafagh department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran reza mirfakhraie molecular pathology research center, imam reza hospital, kermanshah university of medical sciences, kermanshah, iran zahra rostami-far department of biochemistry, school of medicine, kermanshah university of medical sciences, kermanshah, iran reza alibakhshi department of biochemistry, school of medicine, kermanshah university of medical sciences, kermanshah, iran.

about 15% of couples have infertility problems, half of which are related to male factors. cytogenetic and genetic disorders account for about 10% of the male infertility problems. the aim of this study was to determine the frequency and types of both cytogenetic abnormalities and azf microdeletions of y chromosome in idiopathic azoospermic and oligospermic infertile men in west of iran. in thi...

Journal: :Asian journal of andrology 2007
Xin Guo Yao-Ting Gui Ai-Fa Tang Li-Hua Lu Xin Gao Zhi-Ming Cai

AIM To detect the expression of VASA in human ejaculated spermatozoa, and to compare the expression of VASA between normozoospermic men and patients with oligozoospermia. METHODS Ejaculated spermatozoa were collected from normozoospermic men and patients with oligozoospermia by masturbation, and subsequently segregated through a discontinuous gradient of Percoll to obtain the spermatozoa. Rev...

Journal: :Molecular human reproduction 2005
Xin-Jun Yang Toshikatsu Shinka Shiari Nozawa Hong-Tao Yan Miki Yoshiike Mayumi Umeno Youichi Sato Gang Chen Teruaki Iwamoto Yutaka Nakahori

The DAZL (DAZ-like) gene is suggested to be an ancestral gene of the DAZ (deleted in azoospermia) gene on the Y chromosome, which is a strong candidate for the azoospermic factor. Recently, it has been reported that the T54A (Thr54-->Ala) polymorphism in exon 3 of the DAZL gene is associated with spermatogenic failure in the Taiwanese population. In this study, to investigate whether this polym...

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