Although twenty-first century neuroscience is a major scientific enterprise, advances in basic research have not yet translated into benefits for society. In this paper, I outline seven fundamental challenges that need to be overcome. First, neuroscience has to become "big science" - we need big teams with the resources and competences to tackle the big problems. Second, we need to create inter...

No, we’re not making odds for a horse race or betting at a table in Las Vegas! Readers of my column in P&T might recall my discussions of our nation’s performance in health care in previous issues. I’ve noted, with disappointment, that our health care system does not perform as well as those in other nations we like to compare ourselves with. A report from the Commonwealth Fund that caught my a...

Five hundred and twenty seven colorectal carcinomas were reviewed histologically. A multivariate analysis (Cox) was used to test the prognostic importance of certain histological features (invasiveness, inflammatory reaction, and amount of fibrous tissue) at the tumour edge after allowance had been made for clinicopathological stage, tumour site, and histological type and grade. A poorly define...

In this paper, we present new types of web information services, where users and information brokers collaborate in creating a information service. Such services impose a novel task on information brokers: they become responsible for maintaining the inference strategies used in user modeling. In return, information brokers obtain more accurate information about user needs, since the adaptivity ...

George A. Miller said that human beings have only seven chunks in short-term memory, plus or minus two. We counted the number of bunsetsus (phrases) whose modifiees are undetermined in each step of an analysis of the dependency structure of Japanese sentences, and which therefore must be stored in short-term memory. The number was roughly less than nine, the upper bound of seven plus or minus t...

We explore how intra-household bargaining determines human capital investment through a randomised controlled trial that taught girls negotiation skills. We first study the effects of the negotiation training using a lab-in-the-field investment game that simulates parents’ educational investment decisions: negotiation improves outcomes for daughters when they can communicate with their parents,...

Achieving interoperability in health is a challenge and requires standardization. The newly developed HL7 standard: Fast Healthcare Interoperability Resources (FHIR) promises both flexibility and interoperability. This study investigates the feasibility of expressing a Danish microbiology message model content in FHIR to explore whether complex in-use legacy models can be migrated and what chal...

The aqueous solubilities of 27 insecticides and related compounds were determined. Diazinon, fensulfothion and paraoxon had solubilities greater than reported in the literature. The presence of impurities and/or additional components in the mixture altered the measured solubility values. Addition of acetone in amounts up to 1% (volume) produced increases in parathion solubility up to 11%. The p...