We have developed an in vitro motility assay to make a detailed quantitative analysis of Ca2+ control of skeletal-muscle troponin-tropomyosin control of actin-filament movement over immobilized myosin. Ca2+ regulates both filament velocity and the fraction of filaments that are motile. We have demonstrated that the two effects are due to separate interactions of troponin C with troponin I and t...

BACKGROUND The purpose of this study was to derive indices of reperfusion and non-reperfusion after acute myocardial infarction (AMI) from changes in serum concentrations of cardiac troponin T and to test the predictive value of these indices. METHODS The indices were derived from a retrospective analysis of changes in serum troponin T concentration in 71 patients given thrombolytic treatment...

3. Katus HA, Looser S, Hallermayer K, Remppis A, Scheffold T, Borgya A, et al. Development and in vitro characterization of a new immunoassay of cardiac troponin I. Clin Chem 1992;38:386-93. 4. Muller-Bardorif M, Muller G, Hallermayer K, Simon M, Borgya A, Schroder A, et al. Development and characterisation of a specific immunoassay for cardiac troponm T [Abstract]. Eur J Cardiol 1994; 15(Suppl...

Chagas disease is still a major tropical disease in Latin America, affecting 16 to 18 million people. About 6 million people are infected with the causative organism, Trypanosoma cruzi, in Brazil [1]. However, it often remains for decades in its indeterminate form, symptomless, with tissue injury in about 30% of the cases, which eventually will evolve to serious arrhythmia and sudden death [1]....

BACKGROUND Troponin I is the gold standard for the diagnosis of adult acute coronary syndrome. Although it is known that a hypoxic fetus may produce cTnI, fetal cTnI passage in maternal blood has never been documented. CASE REPORT We report a case where the rise of cTnI in the blood of a pregnant woman was not related to maternal heart disease. Instead, it might be suggestive of a fetal cardiac...

OBJECTIVE To describe the use of initial electrocardiogram (ECG), follow-up ECG or equivalent monitoring, and troponin I in patients presenting with sternal fracture who are assessed in emergency departments or by front-line physicians. DESIGN Multicentre descriptive retrospective study. SETTING Two traumatology teaching centres in Quebec city, Que. PARTICIPANTS Fifty-four trauma patients...