PURPOSE Ischemia-reperfusion injury (IRI) is associated with significant patient mortality and morbidity. The complex cascade of IRI is incompletely understood, but inflammation is known to be a key mediator. In addition to the predominant innate immune responses, previous research has also indicated that αβ T cells contribute to IRI in various organ models. The aim of this study was to clarify...

The purpose of this study is to develop methods for determining the biological age (BA) and pace human aging based on anthropometric biochemical laboratory biomarkers, comparing accuracy BA determination using regression neural network analysis. In 735 practically healthy people aged from 20 79, we determined blood plasma concentrations glucose insulin serum total cholesterol, cholesterol high,...

MATERIAL AND METHODS This study prospectively evaluated the progression of liver disease in a group of anti-HCV-positive patients with persistently normal ALT levels (PNALT) who were HCV-RNA positive. Patients selected for this study were those who presented with PNALT according to the Italian Association for the Study of the Liver (AISF) criteria in the year 1995/96 and underwent liver biopsy....

Hepatitis Non A Non B is the commonest type of sporadic hepatitis in Pakistan. To document its clinicopathological pattern, one hundred consecutive cases were studied. The clinical presentation indicates that it is a disease of mild severity presenting with anorexia and dark coloured urine. The rise in serum bilirubin transaminases and alkaline phosphatase is moderate. Monophasic pattern of tra...

Granulomatous hepatitis is a syndrome usually characterized by fever of unknown origin, myalgias, hepatosplenomegaly, and arthralgias, right upper quadrant abdominal pain or tenderness, with or without an elevation in serum transaminases. In this article, we outline our experience with a 64-year-old male presenting with a 3.5 weeks history of fever of unknown origin, night sweats, extreme fatig...

Medications currently available for the treatment of hepatitis B virus (HBV) infection are highly effective but not curative. The current paradigm is to recognize patients who require long-term treatment (with its inconveniences) among the majority of healthy carriers who do not need treatment. International guidelines have been established to identify patients requiring treatment but differenc...

A 16 year old girl with ulcerative colitis developed hepatitis with a high fever, leukopenia and a marked rise in serum transaminases without jaundice. There were no skin, oral, or genital lesions. Liver biopsy was precluded by abnormalities in coagulation. Postmortem examination of the liver by light and electron microscopy, culture, immunoperoxidase and immunofluorescent staining confirmed th...

Serum glutamic oxalacetic transaminase concentrations rise sharply after myocardial infarction prodlucedl by bead embolization of the coronary tree in the closed chest dclog. The peak concentration is reached in 9 to 23 hours post injury. Rises 20 to 30 times greater than normal may be obtained and are directly correlated with the amount of infarction estimated at autopsy. Serial serum transami...

A common reason for a delay in performing the necessary testing and making the correct diagnosis is neonatal age, which is a period in life commonly characterized by the presence of jaundice due to normal physiologic causes and breast feeding, resulting in transiently elevated unconjugated bilirubin levels which are typically self-limited and benign [1,2]. More rarely, neonatal jaundice is simp...