The antidepressant- and anxiolytic-like effects of magnesium, an N-methyl-d-aspartate (NMDA) glutamate receptor inhibitor, were studied in mice using the forced swim test and elevated plus-maze test, respectively. The doses of 20 and 30 mg Mg/kg, reduced immobility time in the forced swim test exerting antidepressant-like activity. In the elevated plus-maze test, magnesium at the same doses pro...

BACKGROUND Low serum magnesium concentrations have been associated with cardiovascular disease risk and outcomes in some general population studies but there are no equivalent studies in diabetes. Metformin may have cardiovascular benefits beyond blood glucose lowering in type 2 diabetes but its association with hypomagnesemia appears paradoxical. The aim of this study was to examine relationsh...

Magnesium, which acts as an antagonist of N-methyl-D-aspartate (NMDA) subtype of glutamate receptors, exerts antidepressant-like activity in animal models of depression. The present study was undertaken to elucidate the influence of sildenafil, a phosphodiesterase type 5 inhibitor, on the anti-immobility action of magnesium in the forced swim test in mice. Swim sessions were conducted by placin...

Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infection...

OBJECTIVE To summarise the potential consequences of atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) and the relationship of the arrhythmia with serum magnesium concentration ([Mg]) and to review the trials of magnesium supplementation as prophylaxis against post-CABG AF. DATA SOURCES Abstracts, articles and published reviews on AF after CABG and magnesium prophylax...

BACKGROUND The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies. METHODS Data included in this analysis consisted of two population-based cross-sectional studies, i.e., the Xiangya Hospital Health Management Center Study and the Xiangya Osteoarthritis (XO) Study I. A bilateral knee anteroposterior radiograph w...

Although there is considerable evidence of the importance of magnesium in disease conditions, studies of magnesium metabolism in patients with leprosy have not been reported. Observations made in the clinical laboratory of this hospital are reported here. The literature is sparse regarding the metabolism of magnesium in man. Studies by Martin et al. (5) indicate that magnesium-free urine does n...

background the anti-inflammatory properties of magnesium sulfate have never been discussed in brain tumor surgeries. objectives this study is aimed to find anti-inflammatory aspects of high dose magnesium sulfate infusion during perioperative period of neurosurgical patients through checking the serial c-reactive protein (crp) blood levels as a biomarker of inflammation. patients and methods si...