Silver-cobalt nanoparticles are used in medicine. In this study, the effects of silver-cobalt nanoparticles on functional tests and liver tissue changes in adult male rats were investigated. 28 adult male Wistar rats weighing 180-220 g were divided into 4 groups of 7. Control group, Experimental group1 received 25mg / kg of silver-cobalt nanoparticles (AgCo NPs) in which silver nanoparticle (Ag...

The hepatic enzyme tyrosine aminotransferase, normally expressed in very low amounts until shortly after birth, is prematurely induced in foetal rats made diabetic by the administration of streptozotocin in utero. Similarly, the enzyme is precociously induced in foetuses if the circulating insulin concentration is artificially decreased by the administration of anti-insulin serum. These observa...

Background: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mi...

Objective(s):The aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. Materials and Methods: Twenty one Wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. Meanwhile, adropin was administrated intraperitonealy...

The purpose of this experiment was to determine the effect of long-term low-dose administration of mercury (Hg) on thyroid function in sheep. In this experiment, 10 clinically healthy, adult, male Iranian sheep, aged approximately 1 year, were randomly allocated into the control (n=5) and mercury (Hg-)-treated (n=5) groups. Both groups were kept under identical conditions in terms of food and e...

Background: This study was conducted to determine the efficacy of milk thistle seeds (MTSs) in counteracting the toxic effects of aflatoxin B1 (AFB1) in a contaminated diet fed to broilers.Methods: Two dietary inclusion rates of AFB1 (0, 0.250 and 500 ppb) and MTS (0, 0.5 and 1%) were tested in a 3×3 factorial manner. The effect of nine experimental treatments was assessed using 216 one-d-old R...

We performed a phase I study of menogaril to determine if dosage reduction was required in patients with hepatic dysfunction and if the relationship between pharmacokinetics and leukopenia, previously de fined in patients with normal hepatic and renal function, was altered. Eighteen patients received 27 courses of menogaril, of which 26 were évaluable for toxicity. Patient characteristics were...

Hematological and blood biochemical parameters are of great importance in medical and veterinary practice. Unfortunately, normal reference range intervals for hematological and serum biochemical values in the tufted capuchin monkey (Cebus apella) have seldom been reported. The study reported here is based on data from blood samples collected from 44 monkeys over an 8-year period. Male and femal...

The protective effects of aqueous extract of Jaggery were evaluated against silica nanoparticles (SNPs) induced toxic manifestations in liver, kidney and lung tissues. Male albino rats were orally treated with Jaggery (400 and 800 mg/kg) for 7 days, after intraperitoneal administration of SNPs (50 mg/kg) for 6 weeks. SNPs administration significantly increased the levels of serum alanine aminot...