Serotonin is a naturally occurring “messenger” protein that is found primarily in the gastrointestinal system, certain blood cells (platelets) and the central nervous system (brain and brain stem). Abnormal activity of this messenger protein has been implicated in both migraine and depression, and medications that modify serotonin can be effective in treating both disorders. Such medications in...

objective: several studies have implicated the 5-httlpr polymorphism in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. the aim of this study was to examine the association between polymorphism in the serotonin transporter gene and citalopram effectiveness in iranian patients suffering from major depressive disorder (mdd). methods: the sample co...

The uptake and release characteristics of dopamine and serotonin in the salivary glands of the locust Locusta migratoria were examined. Cyclic AMP levels were determined in salivary glands in which the salivary nerve was stimulated under different experimental paradigms. Stimulation of the salivary nerve leads to time- and frequency-dependent elevations of cyclic AMP levels in the glands. The p...

Non puerperal lactation or galactorrhea is a well known side effect of antipsychotic drugs but has been infrequently described with the use of antidepressants. In past few decades, there have been emerging trend of isolated case reports of selective serotonin reuptake inhibitors induced non puerperal lactation. We report a case of non puerperal lactation following usage of second generation tri...

Although response interruption and redirection (RIRD) has been shown to be successful in reducing vocal stereotypy, recent reports have suggested that selective serotonin reuptake inhibitors (SSRIs) may also reduce these behaviors. The purpose of the current investigation was to examine the effects of RIRD with and without sertraline on automatically maintained vocal stereotypy of a 4-year-old ...

This article examines the clinical and legal aspects of the involuntary intoxication defense, primarily as it relates to violent acts perpetrated by minor and adult patients who have been prescribed selective serotonin reuptake inhibitors (SSRIs) and related psychoactive medications in a therapeutic context. The Model Penal Code recognizes the involuntary intoxication defense and its potential ...

BACKGROUND It is unclear whether the use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressant drugs reduce the risk of suicide in people with depression. We explored the association between exposure to SSRIs and risk of suicide completion or attempt. METHODS We conducted a systematic review of observational studies that reported completed or attempted suicide in depress...

BACKGROUND AND PURPOSE Selective serotonin reuptake inhibitors (SSRI) are widely prescribed. Several reports have observed an increased bleeding risk associated with SSRI use, which is hypothesized to be secondary to their antiplatelet effect. METHODS We tested the hypothesis that SSRIs increase the risk for or potentiate the risk of hemorrhagic stroke associated with antiplatelets and antico...

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are considered safe and are frequently used during pregnancy. However, two case-control studies suggested an association between prenatal SSRI exposure with childhood autism. AIMS To prospectively determine whether intra-uterine SSSRI exposure is associated with childhood autistic symptoms in a population-based study. METHOD A total...

Background Hemichorea-hemiballism is a syndrome secondary to different etiologies. Drug-induced hemichorea is a rare syndrome related to selective serotonin reuptake inhibitors. To the best of our knowledge, no previous cases of hemichorea associated with sertraline have been reported. Case Report A 65-year-old female noticed hemichorea 1 week after initiation of sertraline. After extensive i...