Serotonin type 3 (5-HT3) receptors are members of the pentameric Cys-loop superfamily of receptors that modulate synaptic neurotransmission. In response to agonist binding and unbinding, members of this superfamily undergo a series of conformational transitions that define their functional properties. In this study, we report the results of electrophysiological studies using rapid solution exch...

The serotonin 2A receptor is one of the most abundant serotonin receptors in the human CNS and is a target for drugs designed to treat psychiatric disorders (McCorvy and Roth, 2015). Significantly, levels of serotonin 2A receptors have been shown to be altered in the CNS of subjects with schizophrenia (Dean, 2003), major depressive disorders (Arora and Meltzer, 1989; Dean et al., 2014) and suic...

NeuroGénétique and Stress, INSERM U471, Institut F. Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment Proc. Abstract Full Text PDF.Corticosteroidserotonin interactions in the neurobiological mechanisms of stress-related disorders. Laurence Lanfumey a,b, Raymond Mongeau a,b, Charles.of acute and chronic stress ...