In many glass-forming liquids, fractional Stokes-Einstein relation (SER) is observed above the glass transition temperature. However, the origin of such phenomenon remains elusive. Using molecular dynamics simulations, we investigate the break- down of SER and the onset of fractional SER in a model of metallic glass-forming liquid. We find that SER breaks down when the size of the largest clust...

Keratin 8 (K8) serine 73 occurs within a relatively conserved type II keratin motif ((68)NQSLLSPL) and becomes phosphorylated in cultured cells and organs during mitosis, cell stress, and apoptosis. Here we show that Ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase. In cells, Ser-73 phosphorylation occurs in association with p38 kinase activation and is inhi...

INTRODUCTION Serine (Ser) is an endogenous amino acid in brain which functions as a co-agonist with glutamate at the NMDA receptor. In disorders of cognition, especially psychosis, alterations in glutamate transmission have been found, possibly including serine signaling [1]. Noninvasive measure of Ser in brain could be pivotal in defining regional tissue pathology. Ser has three coupled resona...

Resumo: Neste artigo, propomos uma reflexão sobre a circulação das mulheres nas cidades, entendendo que os caminhos e as experiências diversas cidades grandes do mundo se diferem, levando em consideração questões de raça classe inseridas ao pesquisarmos essas mulheres. Encontramos o conceito da flâneuse, mulher percorre pela cidade mesmo tempo reflete cria durante esses trajetos, buscando manei...

Caffeine decreases insulin sensitivity and insulin-stimulated glucose transport in skeletal muscle; however, the precise mechanism responsible for this deleterious effect is not understood fully. We investigated the effects of incubation with caffeine on insulin signaling in rat epitrochlearis muscle. Caffeine (≥1 mM, ≥15 min) suppressed insulin-stimulated insulin receptor substrate (IRS)-1 Tyr...

BACKGROUND Human oxoguanine glycosylase 1 (hOGG1) in base excision repair (BER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between hOGG1 Ser326Cys polymorphism and the risk of cancer. However, the results of these studies on the association remain conflicting. To derive a more precise estimation of the association, we conducted a me...

Liberman Z, Plotkin B, Tennenbaum T, Eldar-Finkelman H. Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C II in the diabetic fat tissue. Am J Physiol Endocrinol Metab 294: E1169–E1177, 2008. First published April 22, 2008; doi:10.1152/ajpendo.00050.2008.— Serine/threonine phosphorylation of insulin receptor substrate-1 (IRS-1) is an i...

The largest subunit of RNA polymerase II (RNAPII) C-terminal heptarepeat domain (CTD) is subject to phosphorylation during initiation and elongation of transcription by RNA polymerase II. Here we study the molecular mechanisms leading to phosphorylation of Ser-7 in the human enzyme. Ser-7 becomes phosphorylated before initiation of transcription at promoter regions. We identify cyclin-dependent...