The definition of sepsis was updated to sepsis-3 in February 2016. However, the performance of the previous and new definition of sepsis remains unclear in China. This was a retrospective multicenter study in six intensive care unit (ICUs) from five university-affiliated hospitals to compare the performance between sepsis-1 and sepsis-3 in China. From May 1, 2016 to June 1, 2016, 496 patients w...

neonatal sepsis is a disease of infants who are less than 1 month of age. these infants are clinically ill, and their blood culture are positive for bacteria. the reported incidence of neonatal sepsis for allinfants is 1 to 10 per 1000 live births. the mortality rate is 4.2-26%. the clinical signs are not specific and diagnosis of neonatal sepsis is one of the most difficult tasks in clinical m...

Objective: To analyse the Gram-negative bacteriological profile of nosocomial sepsis and antibiotic susceptibility patterns. Methods: Neonates clinically diagnosed with sepsis and whose blood cultures tested positive for Gram-negative microorganisms from 2002 to 2008, retrospectively. Results: 143 cases of neonatal sepsis caused by Gram-negative microorganisms were identified. Eighty-one percen...

Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1+CD11b+ MDSCs after pro-inflammatory sepsis transitions to the later chronic anti-inflammatory and immunosuppressive phenotype. The purpose of this stu...

Background: Sepsis is one of the most important causes of death in infants. The pattern of bacterial agents responsible for neonatal septicemia changes over time. The main aim of the present study was to provide a clinical guideline adapted for treatment of neonatal sepsis based on the frequency of microbial agents in the Neonatal Intensive Care Unit of Alzahra Hospital, Tabriz, Iran.Meth...

A prospective observational study was conducted in a neonatal unit of referral teaching hospital North India with an aim to the bacteriological profile and sensitivity pattern referred neonates. During this period one year, incidence culture positive sepsis 34 % among which gram-negative bacilli predominated both early onset late sepsis. In sepsis, predominant organism Klebsiella pneumoniae fol...

Sepsis is a potentially fatal response to infection affecting patients across the life span. Sepsis can progress from systemic inflammatory response to severe sepsis and septic shock if not recognized promptly and managed effectively. Risk factors for sepsis include age, gender, the presence of invasive devices (eg, urinary catheters), and chronic medical conditions (eg, chronic obstructive pul...

Aims: to evaluate the quality of life in severe sepsis survivors, using specific QoL questionnaires: the EuroQol-5 Dimensions and the Visual Analogue Scale (EQ-VAS). Method: This case-control study was performed in patients discharged from a teaching hospital after being admitted to the ICU with severe sepsis. Medical records from 349 patients were retrieved from the hospital sepsis registry. E...

INTRODUCTION Patients suffering from sepsis are currently classified on a clinical basis (i.e., sepsis, severe sepsis, septic shock); however, this clinical classification may not accurately reflect the overall immune status of an individual patient. Our objective was to describe a cohort of patients with sepsis in terms of their measured immune status. METHODS Fifty-two patients with sepsis ...

We conducted a 9-month prospective cohort study of 2,527 patients with systemic inflammatory response syndrome in three intensive care units and three general wards in a tertiary health care institution. Markov models were developed to predict the probability of movement to and from more severe stages--sepsis, severe sepsis, or septic shock--at 1, 3, and 7 days. For patients with sepsis, severe...