Various adverse events resulting from, or associated with, benzodiazepine and/or Z-drug use have been extensively reported on and discussed in great detail within the biomedical literature. It is widely accepted that motor vehicle accidents and falls leading to fractures in older adults are major adverse events that have been shown to occur more frequently in users of sedative-hypnotic medicati...

Sedating children for diagnostic and therapeutic procedures remains an area of rapid change and considerable controversy. Exploration of this topic is made difficult by the fact that the reports of techniques and outcomes for pediatric sedation appear in a wide range of subspecialty publications and rarely undergo comprehensive examination. In this review article, we will touch on many aspects ...

Bipolar affective disorder is often poorly controlled by prescribed drugs. Cannabis use is common in patients with this disorder and anecdotal reports suggest that some patients take it to alleviate symptoms of both mania and depression. We undertook a literature review of cannabis use by patients with bipolar disorder and of the neuropharmacological properties of cannabinoids suggesting possib...

Background Hypnotic use in children and adolescents is controversial. Objective To describe the of hypnotic drugs (melatonin, z-drugs, sedating antihistamines) among 5- to 24-year-old Scandinavians during 2012 2018. Methods Aggregate-level data were obtained from public sources Sweden, Norway, Denmark. We calculated annual prevalence (users/1000 inhabitants) stratified by age group, sex, countr...

This study was performed to investigate the sedative-hypnotic activity of γ-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis BJ20). FST and FO were tested for their binding activity of the GABAA-benzodiazepine and 5-HT2C receptors, which are well-known molecular targets for sleep aids. We also ...

327 CBT-I in PTSD—Talbot et al INTRODUCTION As many as 90% of individuals with posttraumatic stress disorder (PTSD) report nightmares and insomnia1,2 and even when nightmares are excluded, sleep disturbance is the most frequently reported symptom of PTSD.3 A survey of Vietnam combat veterans with PTSD showed that 59% to 73% of subjects with PTSD report insomnia and nonrestorative sleep.4 Moreov...

Purpose: This study aimed to identify the status of drug use and analyze effects on falls among older people.Methods: The data were collected from 285 community-dwelling persons through interviewing with questionnaires checking participants’ medication prescriptions drugs using Korea Pharmaceutical Information Center’s (KPIC) website. medications classified into anatomical therapeutic divisions...

Abstract Sleep disorders are common among the general population and can generate health problems such as insomnia anxiety. In addition to standard drugs psychological interventions, there different complementary plant-based therapies used treat This review aimed find examine most recent research on use of herbal medicines for treating anxiety compiled from clinical trials, well assess safety e...