The present studies were carried out in order to assess the protective effects of selenium against cadmium toxicity in pregnant hamsters. On the 8 day of gestation the females were dosed subcutaneously either with cadmium or with cadmium and selenium in the following doses (mg per kilogram of body weight): 0, 1 Cd, 1 Cd + 1 Se, 2 Cd, 2 Cd + 2 Se. In groups treated with cadmium decreased litter ...

Citation: Bocchini M, D’Amato R, Ciancaleoni S, Fontanella MC, Palmerini CA, Beone GM, Onofri A, Negri V, Marconi G, Albertini E and Businelli D (2018) Soil Selenium (Se) Biofortification Changes the Physiological, Biochemical and Epigenetic Responses to Water Stress in Zea mays L. by Inducing a Higher Drought Tolerance. Front. Plant Sci. 9:389. doi: 10.3389/fpls.2018.00389 Soil Selenium (Se) B...

Selenium (Se) is an essential trace element with a wide spectrum of biological activity and as a potential anticancer agent, it has gained a lot of scientific attention. Since the first hypothesis concerning chemopreventive properties of selenium was formulated (in 1969), numerous studies on Se and cancer, including human randomized controlled trials, have been conducted. Whereas studies in viv...

The common oxidation states of selenium found in the environment are selenides (-2), selenium (0), selenites (+4), and selenates (+6). The reduction of selenium oxyanions viz., selenate and selenite to insoluble Se which is less toxic form of selenium, has been reported in numerous bacteria and in some cases thought to be a detoxification mechanism [1]. Selenium reduction mechanisms in anaerobi...

Nonexperimental studies suggest that individuals with higher selenium (Se) status are at decreased risk of cancer. The Nutritional Prevention of Cancer (NPC) study randomized 1,312 high-risk dermatology patients to 200-mcg/day of Se in selenized yeast or a matched placebo; selenium supplementation decreased the risk of lung, colon, prostate, and total cancers but increased the risk of nonmelano...

Selenium (Se) is an essential trace mineral required for growth, development, immune function, and metabolism. Selenium exerts its biological effects as an integral component of selenoproteins (SePs). Deficiency or low Se status leads to marked changes in many biochemical pathways and a range of pathologies and disorders which are associated with SeP function. Animals, and presumably humans, ar...

The authors were asked by the Editors of ACS Chemical Biology to write an article titled "Why Nature Chose Selenium" for the occasion of the upcoming bicentennial of the discovery of selenium by the Swedish chemist Jöns Jacob Berzelius in 1817 and styled after the famous work of Frank Westheimer on the biological chemistry of phosphate [Westheimer, F. H. (1987) Why Nature Chose Phosphates, Scie...

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include the participation in the antioxidant defense the cattle farms. The nutritional requirements of Se in cattle are estimated at 100 μg/kg DM (dry matter) for beef cattle and at 300 μg/kg DM for dai...

Title of Document: EFFECT OF CHITOSAN ON THE INDUCTION OF DNA DAMAGE RESPONSE BY SELENIUM COMPOUNDS. Shu Zhang, Master of Science, 2009 Directed By: Assistant Professor, Dr. Wen-Hsing Cheng, Department of Nutrition and Food Science Selenium (Se), a nutrient trace mineral, plays important roles in optimizing human health. Chitosan is an effective, natural-oriented material for synthesizing nanop...