Neuronal nicotinic acetylcholine receptors (nAChRs) are expressed on hypoglossal motor neurons (XII MNs) that innervate muscles of the tongue. Activation of XII MN nAChRs evokes depolarizing currents, which are important for regulating the size and stiffness of the upper airway. Although data show that chronic developmental nicotine exposure (DNE) blunts cholinergic neurotransmission in the XII...

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of Notch through the γ-secretase inhibitor XII (GSI XII) induces apoptosis of murine MOPC315.BM mye...

The plasma kallikrein-kinin system inhibitor, haemaphysalin, from the hard tick, Haemaphysalis longicornis, was identified. It was found that haemaphysalin inhibited activation of the plasma kallikrein-kinin system by interfering with reciprocal activation between factor XII and prekallikrein. It did not, however, inhibit amidolytic activities of factor XIIa and kallikrein. Direct binding assay...

A near-maximum is an observation which falls within a distance a of the maximum observation in an independent and identically distributed sample of size n. Subject to some conditions on the tail thickness of the population distribution, the number Kn(a) of nearmaxima is known to converge in probability to one or infinity, or in distribution to a shifted geometric law. In this paper we show that...

The effect of local hydrogen concentration on nanoindentation-induced phase transformations has been investigated in ion-implanted amorphous silicon a-Si . Elevated concentrations of H ranging from 5 1018 to 5 1020 cm−3, over the depth of indentation-induced phase transformed zones have been formed in the a-Si by H ion-implantation. Indentation has been performed under conditions that result in...

Fig. 1. Pseudo gray platelets. (A) Blood collected in EDTA 4 hours prior showing aggregated agranular gray platelets (arrow). (B) Blood collected into EDTA showing large and pale agranular platelets. (C) Blood collected into sodium citrate showing normally stained platelets with tiny purple granules. Blood films were prepared immediately after venipuncture (×1,000, Wright-Giemsa stain). hospita...

The functional impact of pulmonary C-fiber activation on upper airway biomechanics has not been evaluated. Here, we tested the hypothesis that pulmonary C-fiber activation alters the respiratory-related control of tongue movements. The force produced by tongue movements was quantified in spontaneously breathing, anesthetized adult rats before and after stimulation of pulmonary C fibers via intr...

Anomaly detection has been proven to be an efficient way detect malicious behaviour and cyberattacks in industrial cyber–physical systems (ICPSs). However, most models are not entirely adapted the real world as they require intensive computational resources labelled data lack interpretability. This study investigated traffic of a coal mine system proposed improved features describe its operatio...

The carbonic anhydrases (CAs) catalyse the hydration of CO2 to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3 is the substrate for several biosynthetic reactions. Carbonic anhydrases are involved in many physiological processes connected with respiration and transport of CO2/bicarbonate between metabolising tissues and the lungs, pH homeostasis and electrol...

this study was carried out for the purpose of investigating the issue of tailings dams as a potential source of contamination by trace elements in soils at the sidi bou othmane mine in the marrakech region, morocco. soil samples taken from depths of up to 15 cm and within a radius of 50 m from the tailings dams, were analyzed for cd, cu, pb and zn using atomic absorption spectrometry. average c...