Figure 1. Computed tomography of the chest demonstrates long, dilated bronchi (short arrow), as well as the cystic " signet ring " lesions (long arrow), which are consistent with bronchiectasis. Diagnosis: common variable immunodeficiency (CVID) with epidermodysplasia verruciformis-like lesions. Epidermodysplasia verruciformis was classically described as a genetic condition involving diffuse w...

BACKGROUND Sebaceous cell carcinoma of the eyelid is a malignant tumor. However, the pathoetiology of sebaceous cell carcinoma is not clear. Retinoic acid (RA) signaling is essential for skin epidermal differentiation including the eyelids. In this study, we investigate the expression of β-catenin, RA-binding proteins and RA receptors in sebaceous cell carcinoma of the eyelid and try to estimat...

Abstrac: Sebaceous gland carcinoma is a rare and fast-growing, potentially lethal skin malignant tumor originating from the adnexal epithelium of sebaceous glands. This more common in superior palpebral than inferior ratio 3:1 elderly with predilection for women. Because it clinically similar to chalazion or chronic inflammatory condition that can cause delays diagnosis. this rarity, we report ...

Epidermodysplasia verruciformis (EV) is regarded as a model for cutaneous oncogenesis associated with specific human papillomaviruses (HPVs). Because genital HPV-associated carcinogenesis is a very long-lasting process requiring 20-30 years and epidemiological studies of this type for HPV-associated skin cancers are impossible in such a rare disease as EV, we observed for up to 20 years EV pati...

Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma...

The single most important causative factor for malignant melanomas of the skin is UV radiation. However, this is not true for melanomas on body surfaces sheltered from the sun; thus, it is important to seek new causative factors of melanoma genesis. Human papillomaviruses and gammaherpesviruses are associated with human skin cancer; for example, human papillomavirus types 5 and 8 are associated...

Sebaceous cell carcinoma of the skin is a rare malignancy of the skin appendages. Most commonly noticed in the orbital region. Extra orbital sebaceous cell carcinoma is extremely rare. The aggressive behavior of this tumor is still a matter of controversy. We present a case of sebaceous cell carcinoma in scalp region in young women.

BACKGROUND Sebaceous carcinoma is notorious for masquerading clinically as other benign lesions such as chalazion. A tool to better differentiate between these two conditions would thus be desirable. PURPOSE To examine the potential application of noninvasive meibography in the differential diagnosis of chalazion and sebaceous carcinoma of the eyelid as a retrospective cross-sectional study. ...

BACKGROUND Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. In this study, we analyzed the Lrig1 expression in human sebaceous tumors. METHODS Twenty-eight ...