BRCA2-deficient sarcomatoid mammary tumors exhibit multi-drug resistance 1 Janneke E. Jaspers, Wendy Sol, Ariena Kersbergen, Andreas Schlicker, Charlotte Guyader, 2 Guotai Xu, Lodewyk Wessels, Piet Borst, Jos Jonkers, Sven Rottenberg 3 4 Authors’ affiliations 5 1 Divisions of Molecular Oncology, 2 Molecular Pathology and 3 Molecular Carcinogenesis, 6 Netherlands Cancer Institute, Plesmanlaan 12...

Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. Sarcomatoid renal c...

INTRODUCTION Patients with neurogenic bladder due to spina bifida are considered to be at increased risk for aggressive bladder cancer. We present a unique case of a 32-year-old woman with spina bifida diagnosed with sarcomatoid urothelial carcinoma of the bladder and report diagnosis and management. CASE PRESENTATION A 32 year old woman with neurogenic bladder managed with intermittent self ...

Cervical sarcomatoid squamous cell carcinoma (SSCC) is an extremely rare malignancy. We report the case of a young woman with cervical SSCC who experienced peri-menopausal syndrome following treatment, and present our evaluation of the considerations relating to hormone replacement therapy (HRT) in this case. A 24-yearold Chinese woman with SSCC underwent radical hysterectomy with bilateral sal...

BACKGROUND Staghorn calculi are well-established risk factors for recurrent urinary tract infections (UTIs) and subsequent renal deterioration. Less commonly, long-term urothelial irritation from a calculus may also pose a risk of malignant transformation. CASE PRESENTATION A 77-year-old male with multiple medical comorbidities presented with a chronic right renal pelvic staghorn calculus and...

Sarcomatoid carcinoma of the small intestine is rare, and only 30 cases have been reported to date. This disease generally exhibits a very poor prognosis. Here we report the case of a 67-year-old man with a sarcomatoid carcinoma in the jejunum, who was hospitalized for diarrhea, fever, nausea, and vomiting. The tumor was located at the jejunum and had a large round shape with geographic necrosi...