BACKGROUND Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF) based on analysis of circulating factors. METHODS Serum concentrations of angiopoietin-2 (Ang-2), follistatin, granulocyte-macrophage-colony stimulating...

The eVects of sarcoidosis on the nervous system are protean. They include involvement of the meninges (cranial nerve palsies, pituitary, and hypothalamic eVects), peripheral nerves (symmetric polyneuropathy, multifocal neuropathy), and brain parenchyma (lesions of brain and spinal cord without obvious meningeal involvement); and also secondary effects of systemic disease, such as intracerebral ...

Intravenous injection of complete Freund's adjuvant (CFA) in rats has been proposed as an experimental model for pulmonary sarcoidosis, but only some animals develop granulomas. Because the detection of the presence of granulomas and evaluation of the extent of the reaction has required histological evaluation, this model has been of limited use in following the evolution of the granulomatous p...

This report is based on 30 deaths from chronic beryllium disease (CBD) in the United Kingdom with details of 19 autopsies. The majority were fluorescent lamp workers and machinists who died from respiratory failure. There were no cases of lung cancer. The survival times ranged from less than 1 to 29 years and was longest in machinists. All of the workers showed interstitial pulmonary fibrosis w...

RATIONALE Receptor expression dictates the spectrum of chemokine actions on immunocompetent cells. We have previously shown that the chemokine receptor CXCR3 is highly expressed by T-helper type 1 (Th1) cells infiltrating the lungs of patients with sarcoidosis. OBJECTIVES The evaluation of the role of Bonzo/CXCR6 and its ligand CXCL16 in the pathogenesis of sarcoidosis. METHODS Immunocompet...

Objecti6e : We have previously observed low levels of high density lipoprotein (HDL) cholesterol in active sarcoidosis. The aim of this study was to analyze the role of serum amyloid A (SAA) on this lipid disorder. Methods : Eighty five untreated sarcoid patients, 40 with active disease and 45 with inactive disease, were recruited. Sarcoidosis activity was evaluated by means of clinical, chest ...

Sarcoidosis is a multisystem disorder of unknown etiology characterized by the presence of non-caseating granulomas in the organs affected. Sarcoid arthropathy is a rare manifestation, and sacroiliitis is an unusual first manifestation of the disorder

Introduction The equine sarcoid is by far the commonest cutaneous neoplasm of horses and the risk factors that predispose to its development in an individual have only partially been identified. The disease is becoming more prevalent and yet there is still little interest in advancing research efforts. It affects horses of all ages, although the majority of cases are first presented between 2 a...

in patients with malignancy, the common etiologies of granuloma formation are tumor related sarcoid reaction, sarcoidosis, tuberculosis and other granulomatous diseases. often, the finding of granulomas in malignant patients may obscure the primary malignancy or may mislead towards treatment of infectious and other etiologies. hence, their proper recognition and necessary follow up is needed to...

We investigated the effect of inhaled corticosteroids on the phenotypes and functional capacity of macrophages obtained by bronchoalveolar lavage from patients with pulmonary sarcoidosis. The results were correlated with clinical status and therapeutic efficacy. Ten symptomatic sarcoid patients (previously untreated) with radiological parenchymal shadowing and abnormal pulmonary function receiv...