The water soluble benzodiazepine derivative, midazolam, is used almost exclusively at our institution to produce sedation for numerous surgical procedures. Mild arterial oxygen desaturation has been reported in patients who have received as little as .04 mg/kg. A time series design study was undertaken to determine if there was any correlation between the decline in arterial oxygen percent satu...

OBJECTIVES We compared the efficacy of the standard nasal cannula and the demand oxygen delivery system (DODS) during sleep in patients with COPD. SUBJECTS Twenty patients with moderate or severe COPD were included in the study. METHODS Four consecutive polysomnographic recordings were performed under the following conditions: DODS powered by compressed air (night 1 [N1]); oxygen delivered ...

BACKGROUND The pandemic influenza A (H1N1) virus emerged during 2009 and has spread worldwide. This virus can cause injuries to the lungs, liver, and heart. However, data regarding whether this influenza virus can affect pancreatic islets are limited. We investigated the effects of influenza A (H1N1) pneumonia on fasting plasma glucose (FPG) and islet function, and evaluated possible correlatio...

During the COVID-19 pandemic, trusts across London aimed to discharge patients with oxygen saturations (SaO2) of 90–94%, due concerns regarding limited hospital resource both inpatient beds and supplemental oxygen. However, safe these from emergency

Exercise tolerance may be reduced in patients with cystic fibrosis, but it is not always possible to predict this from standard lung function measurements. Formal exercise testing may, therefore, be necessary, and the test should be simple and readily available. We have developed a "3-minute step test" and compared it with the standard 6-minute walking test. Subjects stepped up and down a 15-cm...

We evaluated the accuracy and speed of response of a newly available, lightweight, and relatively inexpensive ear oximeter (Biox II oximeter). The instrument was compared with another oximeter (Hewlett-Packard 47201A) under conditions of both steadily maintained and progressively increasing hypoxia induced in normal subjects by rebreathing. The new oximeter (Biox II), which can be operated in e...

Abstract Objectives To describe the outcomes of postoperative tracheostomy and determine predictors survival. Design Prospective, observational study. Setting Cardiac surgical intensive care unit a tertiary hospital. Participants All pediatric patients below 10 years age who underwent after cardiac surgery from January 2019 to December 2019. Different variables were compared between survivors n...

The responses to exercise were studied in 41 patients with pulmonary fibrosis, in whom vital capacity (VC) was reduced to 62% of predicted normal values. Maximum power output (POmax) was 53% predicted; there was a significant relationship between POmax and VC (r = 0.564). The maximum ventilation achieved during exercise was also related to VC (r = 0.614). Although arterial oxygen saturation (Sa...

One hundred and eleven children with acute asthma were studied to compare delivery of terbutaline by either a metered dose inhaler (MDI) with a valved holding chamber or a nebuliser driven by air. Eligible patients were randomised; the MDI group received three puffs (0.75 mg) of terbutaline and the nebuliser group received 2 ml (5.0 mg) terbutaline solution diluted with 2 ml 0.9% saline for inh...

BACKGROUND Despite the fact that numerous studies have pursued the strategy of improving collateral function in patients with peripheral artery disease, there is currently no method available to quantify collateral arterial function of the lower limb. METHODS AND RESULTS Pressure-derived collateral flow index (CFIp, calculated as (occlusive pressure-central venous pressure)/(aortic pressure-c...