This study evaluated cholineresterase inhibitory activity of Korean white ginseng extract (WGE), red ginseng extract (RGE), and black ginseng extract (BGE) and the cholinergic effect on scopolamine (SCOP)-induced amnesic mice. WGE, RGE, and BGE inhibited acetylcholineserase (AChE), as well as butyrylcholineserase (BuChE) in a concentration-dependent manner. BGE presented strong inhibition of AC...

Comparative studies of the proteomes from different organisms have provided valuable information about protein domain distribution in the kingdoms of life. Earlier studies have been limited by the fact that only about 50% of the proteomes could be matched to a domain. Here, we have extended these studies by including less well-defined domain definitions, Pfam-B and clustered domains, MAS, in ad...

In the framework of collection and identification of bolete fungi of Iran, one specimen from the genus Strobilomyces was collected and identified as Strobilomyces strobilaceus (Scop.) Berk., based on Knudsen & Vesterholt (2008).

We consider a well-known NP-hard deterministic inventory control problem: the One-Warehouse Multi-Retailer (OWMR) problem. We present a simple combinatorial algorithm to recombine the optimal solutions of the natural single-echelon inventory subproblems into a feasible solution of the OWMR problem. This approach yields a 3approximation. We then show how this algorithm can be improved to a 2-app...

MOTIVATION Modeling of protein interactions is often possible from known structures of related complexes. It is often time-consuming to find the most appropriate template. Hypothesized biological units (BUs) often differ from the asymmetric units and it is usually preferable to model from the BUs. RESULTS ProtBuD is a database of BUs for all structures in the Protein Data Bank (PDB). We use b...

In this paper we deal with structured software fault-tolerance. Structured software fault tolerance are those techniques where redundancy (both for detection and correction) is applied to the individual blocks of software with the goal of masking or reveal errors internal to the block. Each technique has its own way of structuring the interactions among redundant parts and of managing the compl...

Lesions of the amygdala impair performance on a conditioned place preference (CPP) but not a spatial radial maze task. The role of cholinergic receptors within the amygdala in performance of these tasks was evaluated using intra-amygdala injections of the muscarinic receptor antagonist, scopolamine. Food deprived rats were trained on a CPP task, which consisted of four training trials on two ar...

We present the Database of Disordered Protein Prediction (D(2)P(2)), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (m...

Structural genomics aims to solve a large number of protein structures that represent the protein space. Currently an exhaustive solution for all structures seems prohibitively expensive, so the challenge is to define a relatively small set of proteins with new, currently unknown folds. This paper presents a method that assigns each protein with a probability of having an unsolved fold. The met...