Deoxycytosine methylase (Dcm) enzyme activity causes mutagenesis in vitro either directly by enzyme-induced deamination of cytosine to uracil in the absence of the methyl donor, S-adenosylmethionine (SAM), or indirectly through spontaneous deamination of [5-methyl]cytosine to thymine. Using a Lac reversion assay, we investigated the contribution of the first mechanism to Dcm mutagenesis in vivo...

Previously, we identified an amplified gene in a stomach cancer cell line, KATO-III, and designated it K-sam. This gene was later found to be identical with a gene for a receptor tyrosine kinase, bek/FGFR2. One of the characteristics of the K.sam gene is structural diversity of its transcripts; K-sam complementary DNA (cDNA) cloned from human brain (K-sam-I) has a completely different sequence ...

Previously, we identified an amplified gene in a stomach cancer cell line, KATO-III, and designated it K-sam. This gene was later found to be identical with a gene for a receptor tyrosine kinase, bek/FGFR2. One of the characteristics of the K.sam gene is structural diversity of its transcripts; K-sam complementary DNA (cDNA) cloned from human brain (K-sam-I) has a completely different sequence ...

Although In our geological textbooks the undertow has been described as a well known phenomenon, some doubts have been expressed In recent years as to Its reality. This question was first raised by Professor W. M. Davis In 1925 as the result of some observations made by him along the Florida coast. A few years later independent investigations regarding the existence of the undertow were made by...

This paper investigates the approximation behaviour of the K1 oczy–Hirota (KH) interpolative fuzzy controllers. First, in accordance with the remarks in (Fuzzy Sets and Systems 125(1) (2002) 105), it is pointed out that it is a fuzzy generalization of the Shepard operator. Shepard operator has thoroughly studied by approximation theorist since the mid-1970s. Exploiting the aforementioned relati...

Identification of acid-fast bacteria failing to grow on artificial culture media under known conditions as Mycobacterium leprae now depends on the results of two time-consuming tests. At relatively low ambient temperatures, several thousand leprosy bacilli multiply within 6 to 9 months to maximal numbers of several million in the mouse footpad. Gross lesions or invasion of adjacent or remote ti...

The problem of modeling and visualization of scattered data where there are inherent constraints on value of the data exists in many scientific and business research areas. For example, the value of mass concentration always has the lower bound of 0 and upper bound of 1. The modeling functions having gradient continuity usually do not guarantee to preserve the bounds of data. In this paper we p...