A growing body of evidence demonstrates that Akt may serve as a therapeutic target for treatment of early brain injury following subarachnoid hemorrhage (SAH). The purpose of the current study was to evaluate the neuroprotective effect of Akt specific activator SC79 in an experimental rat model of SAH. SAH was induced by injecting 300 μL of blood into the prechiasmatic cistern. Intracerebrovent...

Oxidative stress and inflammation play an important role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The present study aimed to evaluate the effect of salvianolic acid A (SalA) on EBI after SAH via its antioxidative, anti-inflammatory, and anti-apoptotic effects. The intraperitoneal administration of SalA (10 and 50 mg/kg/day) significantly alleviate...

Stable single-alpha helices (SAHs) are versatile structural elements in many prokaryotic and eukaryotic proteins acting as semi-flexible linkers and constant force springs. This way SAH-domains function as part of the lever of many different myosins. Canonical myosin levers consist of one or several IQ-motifs to which light chains such as calmodulin bind. SAH-domains provide flexibility in leng...

Epidemiological studies of the relationship between climate and the onset of aneurysmal subarachnoid hemorrhage (SAH) have been reported in the temperate and subarctic latitudes. However, the relationship between the incidence of aneurysmal SAH and the climatic variations in the subtropical region remains uncertain. Epidemiological analysis requires study of an extremely isolated area. This stu...

Results The CT images in each patient revealed diffuse hyperdensity in the basal cisterns in an appearance similar to aneurysmal SAH. None of the patients had the typical distribution of nonaneurysmal perimesencephalic-SAH. In two of the patients, the prospective CT interpretation by the radiologist cited true SAH as the etiology of this increased attenuation within the subarachnoid spaces. In ...

Quercetin has been demonstrated to play an important role in altering the progression of ischemic brain injuries and neurodegenerative diseases by protecting against oxidative stress. The effects of quercetin on brain damage after subarachnoid hemorrhage (SAH), however, have not been investigated. This study was designed to explore the effects of quercetin on oxidative stress and brain edema af...

BACKGROUND AND PURPOSE Subarachnoid hemorrhage (SAH) can leave patients with memory impairments that may not recover fully. Molecular mechanisms are poorly understood, and no treatment is available. The sulfonylurea receptor 1-transient receptor potential melastatin 4 (Sur1-Trpm4) channel plays an important role in acute central nervous system injury. We evaluated upregulation of Sur1-Trpm4 in ...

BACKGROUND AND PURPOSE Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysis of risk factors for SAH from our population-based, case-control study. ME...

It is gratifying to read that Liu et al. (1) confirmed our hypothesis regarding the desirability of measuring S-adenosylhomocysteine (SAH or AdoHcy); however, we have 2 concerns about the paper by Liu et al. First, to determine SAH in mouse plasma, the critical measurement, the authors adapted the method of Frantzen et al. (2) that was designed for the immunoassay of homocysteine (Hcy). This me...

BACKGROUND AND PURPOSE Hyponatremia has been shown in association with cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage (SAH). In the past few years there has been increasing evidence that brain natriuretic peptide (BNP) is responsible for natriuresis after SAH. The purpose of the present study was to investigate the relationship between BNP plasma concentrations and CVS af...