A synthetic analogue of glucose, 2-deoxy-D-glucose (2-DG), stimulates vagal hypothalamic centres by lowering intracellular glucose levels. This substance has been used to elicit the vagal phase of gastric secretion in the rat, dog, and man (Baume, Nicholls, Barnett, and Room, 1966; Hirschowitz and Sachs, 1965; Duke, Hirschowitz, and Sachs, 1965). The acid response to 2-DG is equal to that produ...

A method for the preparation of highly purified @-hexosaminidase isozymes A and B from human placenta is presented. The purified enzymes possess identical molecular weight and exhibit similar kinetic parameters with artificial fluorogenic substrates. Both enzymes catalyze the hydrolysis of Tay-Sachs ganglioside (Cer-Glc-Gal(NeuAc)-GalNAc) and the corresponding asialo-derivative (Cer-Glc-GalGalN...

Tay-Sachs and Sandhoff diseases are lysosomal storage disorders that result from an inherited deficiency of beta-hexosaminidase A (alphabeta). Whereas the acute forms are associated with a total absence of hexosaminidase A and early death, the chronic adult forms exist with activity and protein levels of approximately 5%, and unaffected individuals have been found with only 10% of normal levels...

Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the α-subunit of lysosomal β-hexosaminidase A, which converts G(M2) to G(M3) ganglioside. Hexa(-/-) mice, depleted of β-hexosaminidase A, remain asymptomatic to 1 year of age, because they catabolise G(M2) ganglioside via a lysosomal sialidase into glycolipid G(A2), which is further processed by β-h...

Jeffrey Sachs is the economics profession’s leading advocate of mega-reform. Whether it is stabilization of hyperinflation in Bolivia, shock therapy to leap from Communism to capitalism in Poland and Russia, or a “Big Push” to end world poverty , Sachs’ recommendation throughout his career has been to do it fast, do it big, do it comprehensively, and do it with lots of Western money. Sachs’ app...

The pedagogical imagination: the republican legacy in twenty-first-century French literature and film / Leon Sachs. pages cm Summary: " Study of French education and republicanism as represented in twenty-first century French literature and film " — Provided by publisher.

The relation between gravitational memory effects and Bondi-Metzner-Sachs symmetry of the asymptotically flat spacetimes is studied in scalar-tensor theory. For this purpose, solutions to equations motion near future null infinity are obtained generalized Bondi-Sachs coordinates with a suitable determinant condition. It turns out that group also semi-direct product an infinitesimal dimensional ...

Cartan torsion contribution to Sachs-Wolfe effect in the inflationary phase of the Universe is discussed.From the COBE data of the microwave anisotropy is possible to compute the spin-density in the Universe as 10 mks units.The spin-density fluctuations at the hadron era is shown to coincide with the anisotropy temperature fluctuations. PACS number(s) : 0420,0450 Departamento de F́ısica Teórica ...

We have detected statistically significant correlations between the cosmic microwave background and two tracers of large-scale structure, the HEAO1 A2 full sky hard X-ray map (Boldt, 1987) and the NVSS 1.4 GHz, nearly full sky radio galaxy survey (Condon et al., 1998). The level of correlations in these maps is consistent with that predicted for the integrated Sachs-Wolfe (ISW) effect in the co...

A holographic correspondence between horizon data and space-time physics is investigated. We find similarities with the AdS/CFT correspondence, based on the observation that the optical metric near the horizon describes a Euclidean, asymptotically anti-de Sitter space. This picture emerges for a wide class of static space-times with a non-degenerate horizon, including Schwarzschild black holes ...