of a dissertation at the University of Miami. Retinal ganglion cells (RGCs) as well as other CNS neurons do not regenerate after injury and die soon after. While significant progress has been made in understanding the molecular basis for this lack of regenerative ability, this knowledge has not been enough to generate effective therapeutic strategies to promote axonal regeneration or prevent ce...

Dear Editor, Two cases with epiphora and medial canthal mass showed a cyst within the lacrimal sac that compressed the lacrimal drainage system. We describe a new lacrimal sac anomaly of lacrimal intrasaccal cyst, which has not yet been reported. A 31-year-old woman was referred for epiphora in her left eye for 17 years. She also presented with a 10-year history of a palpable mass below the med...

Yolk sac hematopoiesis is characterized by restricted hematopoietic cell differentiation. Although multipotent hematopoietic progenitor cells have been identified in the early yolk sac, long-term multilineage repopulating (LTMR) hematopoietic stem cell (HSC) activity has not been demonstrable before day 11 postcoitus (PC) using standard transplantation assays. In the present study, day-10 PC yo...

BACKGROUND Hepatocellular carcinoma (HCC) is highly malignant and metastatic. Currently, there is no effective chemotherapy for patients with advanced HCC leading to an urgent need to seek for novel therapeutic options. We aimed to investigate the effect of a garlic derivative, S-allylcysteine (SAC), on the proliferation and metastasis of HCC. METHODOLOGY/PRINCIPAL FINDINGS A series of in vit...

AIMS Apoptosis of cardiomyocytes significantly contributes to the development of post-ischaemic cardiomyopathy. Although mitochondria have been suggested to play a crucial role in this process, the precise mechanisms controlling the mitochondria-dependent apoptosis in cardiomyocytes under ischaemia/reperfusion are still poorly understood. Here we aimed to analyse the role of the soluble adenyly...

In this study, acesulfame (ACE), saccharin (SAC) and cyclamate (CYC) were found in all paired urine and blood samples collected from healthy adults, with mean values of 4070, 918 and 628 ng mL(-1), respectively, in urine and 9.03, 20.4 and 0.72 ng mL(-1), respectively, in blood. SAC (mean: 84.4 ng g(-1)) and CYC (4.29 ng g(-1)) were detectable in all liver samples collected from liver cancer pa...

SAC is a purely functional array processing language designed with numerical applications in mind. It supports generic, high-level program specifications in the style of APL. However, rather than providing a fixed set of builtin array operations, SAC provides means to specify such operations in the language itself in a way that still allows their application to arrays of any dimension and size....

Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in m...

OBJECTIVES/HYPOTHESIS The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the innate immune system in the human endolymphatic sac. It is hypothesized that the endolymphatic sac has a significant immunological function in the human inner ear. STUDY DESIGN DNA microarrays and immunohistochemistry were used for analyses of fresh human endo...

In this study, we investigated the effects of polymers on pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as active ingredient (API), nicotinamide (NIC) and saccharin (SAC) coformer (CCF), ethanol/water solvent, polyvinylpyrrolidone (PVP) poly (ethylene glycol) (PEG) representative polymers. We prepared IBU-NIC IBU-SAC cocrystals in ethanol-water cosolvent absence or pr...