A cassette vector has been constructed which allows the rapid and extensive modification of one of the neutralizing antigenic sites of the Sabin 1 poliovirus vaccine strain, P1/LSc 2ab. Unique restriction endonuclease sites flanking antigenic site 1 have been engineered into a full-length infectious Sabin 1 cDNA clone with minimal alteration to the coding sequence. This facilitates replacement ...

We derive a geometric criterion for the convexity of Powell-Sabin interpolants and present a multivariate generalization.

Author Affiliations: Service de Médecine Interne, Centre Hospitalier National d’Ophtalmologie des QuinzeVingts, Paris, France (Drs Feldman-Billard and Héron); and Service d’Ophtalmologie (Dr Massin) and Service de Médecine Interne B (Drs Meas and Guillausseau), Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, Paris. Correspondence: Dr Feldman-Billard, Service d...

Rothko Chapel is Morton Feldman's most distinctive piece. The processes of musical development in this work also deviate from traditional Feldman. Contrary to the emphasis on uniqueness that several scholars have explored. Firstly, paper provides a detailed account Feldman’s oeuvre and its analytical difficulties, followed by an overview existing approaches analysis Chapel. And finally, selecte...

Submit Manuscript | http://medcraveonline.com Abbreviations: BCG: Bacille Calmette-Guerin Vaccine; CI: Confidence Interval; CD4, CD8: A Type of White Blood Cell Help to Defend the Body from Infections; DNA: Deoxyribonucleic Acid; EPI: Expanded Program on Immunizations; GAVI: Global Alliance for Vaccines and Immunization; HIV: Human Immunodeficiency Virus; IAVI: International AIDS Vaccine Initia...

AIMS To assess the diagnostic usefulness of Toxoplasma gondii tachyzoites produced by serial passage in HeLa cell culture. METHODS Tachyzoites derived from serial passage in cell culture were used in the dye test. Human sera were also examined to determine their suitability for use as accessory factor. Using the optimum conditions, the dye test using cell culture derived tachyzoites was compa...

Figure 1. Fluctuation of capsid protein homology to Sabin 2 and viral stool excretion in serial stool samples from the paralysis case-patient (PC, left) and the asymptomatic contact with prolonged excretion (AC3, right). Time of sampling is included in the x-axis; homology percentage with respect to original Sabin 2 strain (X00595) and viral load in stools are in y-axis, left and right, respect...