The S100 family of EF-hand calcium (Ca(2+))-binding proteins is essential for a wide range of cellular functions. During infection, certain S100 proteins act as damage-associated molecular patterns (DAMPs) and interact with pattern recognition receptors to modulate inflammatory responses. In addition, these inflammatory S100 proteins have potent antimicrobial properties and are essential compon...

INTRODUCTION The results of a clinical trial to evaluate the efficacy and safety of initial combination therapy with sitagliptin and metformin in Chinese patients with type 2 diabetes and inadequate glycemic control are reported here. MATERIALS AND METHODS This was a multicenter, randomized, double-blind, placebo-controlled, parallel group, 24-week clinical trial carried out in China. Patient...

background : this study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. however, their clinical significance in epithelial ovarian cancer is not c...

 Schwannomas are benign neoplasms with unknown etiology, which apparently arise from neural sheath Schwann cells. Intraoral schwannomas are solitary, slow-growing lesions occurring at different ages; these lesions are normally asymptomatic and in some cases, they are accompanied by pain and paresthesia if spotted in the intraosseous regions of the mandibles. Definitive diagnosis of schwannoma i...

S100 proteins are acidic low molecular weight members of a family of calcium-binding proteins that were originally identified in the nervous system [1,2], S100 proteins have since been localized to several neuronal and non-neuronal cells, including adrenal chromaffin cells and skeletal muscle cells, in addition to glial cells and neurons [3]. The two “classic” S100 proteins were given the desig...

STUDY OBJECTIVE A computed tomography (CT) scan has high sensitivity in detecting intracranial injury in patients with minor head injury but is costly, exposes patients to high radiation doses, and reveals clinically relevant lesions in less than 10% of cases. We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury. METHODS We conduc...

S100 protein family has been implicated in multiple stages of tumorigenesis and progression. Among the S100 genes, 22 are clustered at chromosome locus 1q21, a region frequently rearranged in cancers. S100 protein possesses a wide range of intracellular and extracellular functions such as regulation of calcium homeostasis, cell proliferation, apoptosis, cell invasion and motility, cytoskeleton ...

leiomyoma is a rare esophageal tumor that constitutes less than 1% of esophageal malignancies. it should be removed when diagnosed even if asymptomatic. this study presents two cases of esophageal leiomyoma in 38 and 62 years old men who presented with dysphagia and evaluated for diagnosis and location of related tumors. patients were clinically examined and upper gastrointestinal endoscopy, ch...

S100 beta produced in Escherichia coli from a synthetic gene (Van Eldik, L. J., J. L. Staecker, and F. Winningham-Major. 1988. J. Biol. Chem. 263:7830-7837) stimulates neurite outgrowth and enhances cell maintenance in cultures of embryonic chick cerebral cortex neurons. In control experiments, the neurite extension activity is reduced by preincubation with antibodies made against bovine brain ...