Histological Study. The sections examined were variably pigmented. The anterior layers of the cornea were involved with destruction of the epithelium and of Bowman's membrane (Fig. 3, opposite). The cells, which were predominantly epithelioid in type with vesicular nuclei and a fair amount of cytoplasm, were arranged in alveolar and naevus patterns with thin intervening fibrous strands. Squamou...

A 32-year-old woman had several brownish and pruritic lesions over her left buttock and leg that had been present since she was 12 years old. She observed a progressive increase in size and number of the lesions, with increased sweating on and around them. Examination revealed several brownish, irregular nodules, 1–1.5 cm in diameter, and firm to palpation, along the lower left limb and followi...

Aim:Spitz naevus is a benign melanocytic tumour with distinct histopathological features of spindle-shaped melanocytes. An understanding genetic aberrations can help to characterise the different subsets Spitzoid neoplasms. Anaplastic lymphoma kinase (ALK) tyrosine receptor that was first described in pathogenesis anaplastic large cell (ALCL). ALK mutations have been reported up 10% Spitz tumou...

While population screening for melanoma is not recommended, those at high risk could lead to earlier detection and improved patient outcomes. Current stratification largely based on subjective clinical assessment self-report. This time-consuming dependent the experience understanding of person reporting. Therefore, improved, standardized methods are required. We developed an automated skin surf...

Sir, Porokeratotic eccrine ostial and dermal duct naevus (PEODDN) is a rare disorder of keratinization with eccrine involvement that histologically presents a cornoid lamella exclusively associated with eccrine ostia and the underlying sweat ducts (1). It is an expression of genetic mosaicism (2) and is characterized by asymptomatic grouped keratotic papules and plaques with a linear distributi...