The pathogenesis of immunodeficiency-associated lymphoma is poorly understood. During the past several years, numerous lines of evidence implicating a multistep process of malignant transformation, also known as sequential pathogenesis, have emerged. Tumor-associated macrophage production of specific lymphostimulatory products has been demonstrated and hypothesized to be central to this process...

To study the putative agent(s) related to Crohn disease, we intraperitoneally in injected mesenteric lymph node homogenates from four patients with active Crohn disease into 10-week-old athymic (nu/nu) mice. Control mice (nu/nu) were injected with homogenates of mesenteric lymph nodes from two patients with ulcerative colitis and four patients undergoing elective cholecystectomy, and with a hom...

The astute clinician occasionally detects herald or concurrent signs of systemic disease in the mouth, perianal area or genitalia. Surgical pathologists are familiar with testicular lymphoma,1 while scrotal2 and vulval3 4 lymphoma are rare. Genital vasculitis may either be isolated or a part of systemic disease and occurs more usually in the testis or spermatic cord.5 Penile polyarteritis nodos...

Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node. The gastrointestinal tract is the predominant site of extranodal involvement in the form of multiple lymphomatous polyposis. Multiple lymphomatous polyposis due to mantle cell lymphoma presenting with intussusception is ...

Primary breast lymphoma represents less than 1% of all primary breast malignancies and most primary breast lymphomas are of B-Cell origin. The association of anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL), a very rare form of primary breast lymphoma, with silicone-filled breast implants has been suggested and several case reports supported this proposal, especia...

Gynecological lymphoma is one of the rarest tumors of the female organs that need to be kept in mind in a suspected patient due to its different management protocol. Even though the reported cases of ovarian lymphoma are not limited; our knowledge about diagnosis and treatment of primary cervical lymphoma is restricted. There is a rising number of suggested imaging and pathological criteria tha...