one of the most serious neurodegenerative disorders is alzheimer disease (ad). as the population is aging and due to the fact that ad is more common in aged people, more attention must be paid to this disease. one of the main characteristics of ad is dementia which starts with loss of short term memory, then progresses and causes various brain dysfunctions such as loss of long term memory. inte...

BACKGROUND AND PURPOSE To evaluate the relationship between arterial stiffness and cognitive function in a population of elderly subjects reporting memory loss. METHODS We studied the association between cognitive function and arterial stiffness in 308 consecutive elderly subjects attending a geriatric outpatient clinic reporting memory impairment. Subjects were classified into 4 categories a...

Background: Alzheimer’s Disease is the most common cause of dementia, affecting memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. AD predicted increase healthcare spending costs associated formal informal caregiving. The aim this study was identify quantify contribution different cost components AD. Methods: A structured literature review condu...

AIMS To investigate the incidence and severity of the 'head-turning sign' (HTS), i.e. turning the head back to the caregiver(s) for help, in patients with various dementias and discuss its clinical specificity in Alzheimer's disease (AD). METHODS WE INVESTIGATED THE INCIDENCE AND SEVERITY OF HTS WHILE ADMINISTERING A SHORT COGNITIVE TEST (THE REVISED HASEGAWA DEMENTIA RATING SCALE: HDSR) in o...

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer's disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level...

background and objective: alzheimer’s disease (ad) is a neurodegenerative disorder specified by deposition of b-amyloid (ab) and neuronal loss that leads to learning and memory disturbances. one of the most important causes of ad is glutamate-dependent excitotoxicity in brain regions that is vulnerable to ad. according to previous reported results, it was revealed that riluzole, as a glutamate ...

Alzheimer's disease (AD), the most ordinary form of dementia and extracellular accumulation of Amyloid-&beta; (A&beta;) in senile plaques, is an important and a main event in the pathogenesis of AD. Deposition of A&beta; Peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. Recently, a novel inflammasome signaling&n...

AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may critically contribute to the development and progression of both AD and atherosclerosis. An increased risk of developing AD is linke...