Dieda ointment, a Chinese medicine, has been widely used in the clinical treatment of fracture after years research to prove that it significant effects on healing injury and relieving pain, reinforcing tendons setting bones. However, mechanism its is still unclear. The purpose this study was explore ointment promoting healing. materials methods explored were establish model Sprague-Dawley rats...

Abstract Background Acute myeloid leukemia represents the highest percentage of all adult acute variants. Runt-related transcription factor1 ( RUNX1 ), a factor with known tumor suppressor function, was recently reported as promoter in (AML). We investigated role gene expression level Egyptian AML patients and delineated its clinical significance. Results measured using reverse transcription-qu...

Abstract Kidney cancer is the third most common malignancy of urinary system, which, kidney renal clear cell carcinoma (KIRC) accounts for vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, diverse expression patterns and prognostic values RUNX genes remained to be elucidated. In our study, we mined DNA methylation, transcriptional sur...

BACKGROUND Runt-related transcription factor 3 (RUNX3) is a member of the runt-domain family of transcription factors. Emerging evidence indicates that RUNX3 is a tumor suppressor gene in several types of human cancers including esophageal cancer. However, the association between RUNX3 promoter methylation and esophageal cancer remains unclear. Here we conducted a systematic review and meta-ana...

Each of the two human genes encoding the alpha and beta subunits of a heterodimeric transcription factor, PEBP2, has been found at the breakpoints of two characteristic chromosome translocations associated with acute myeloid leukemia, suggesting that they are candidate proto-oncogenes. Polyclonal antibodies against the alpha and beta subunits of PEBP2 were raised in rabbits and hamsters. Immuno...

Previously (1) it was demonstrated that, in the strain combination of mice under study, acquired tolerance to skin homografts was lost with increasing age. The chronic rejection pattern suggested a host versus graft reaction which increased in severity with time, culminating in the elimination of donor lymphoid cells and skin grafts. Since the rejection of homologous tissues by normal animals i...