background: major histocompatibility complex (mhc) comprises a group of genes, which plays a central role in immune response. the exon 2 of bula-drb3 is part of the mhc class ii in buffalo that highly polymorphic, found to be associated with resistance/susceptibility to infections and also with production parameters. objectives: the purpose of the present study is to identify bula-drb3 polymorp...

The dramatic shift in the pathological presentation of lung cancer [the proportional decrease in squamous cell carcinoma (SCC) and increase in adenocarcinoma (AC)] observed in the United States after the 1950s may have taken place as the result of the reduction in polycyclic aromatic hydrocarbons (PAHs) and the increase in N-nitrosamines in inhaled smoke from filtered low-yield cigarettes. The ...

BACKGROUND Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women. METHODS PubMe...

Genetic polymorphisms in enzymes involved in carcinogen metabolism have been shown to influence susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is primarily responsible for the bioactivation of many low molecular weight carcinogens, including certain nitrosamines, whereas glutathione S-transferases (GSTs) are involved in detoxifying many other carcinogenic electrophiles. Esophageal cance...

Genetic polymorphisms in enzymes involved in carcinogen metabolism have been shown to influence susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is primarily responsible for the bioactivation of many low molecular weight carcinogens, including certain nitrosamines, whereas glutathione S-transferases (GSTs) are involved in detoxifying many other carcinogenic electrophiles. Esophageal cance...

Background: Selection based on traits such as average daily gain (ADG) and carcass quality in commercial pig populations have drawn attention of swine breeders due to the correlation with growth consumer preference for composition, respectively. The association between melanocortin 4 receptor (MC4R) gene, which encodes G-protein-coupled ADG quality, been well documented. study was conducted det...