The environmental effects of nanoplastics-NPLs have been addressed mainly through short-term exposures to a few types polymers, neglecting other NPLs that are economically relevant like polymethylmethacrylate - PMMA. This work aimed assess long-term PMMA-NPLs on the marine primary consumer Brachionus plicatilis, evaluating influence different exposure routes (waterborne, foodborne and both) foo...

(S-180) by several bisthiosemicarbazones of a-ketoalde hydes was initially reported by French and Freedlander (5, 6). More recently, other compounds of this type have been found to cause marked inhibition of the growth of Walker carcinosarcoma 256 (W-256) and of two other transplantable rat tumors (19, 21). Striking antitumor effects were obtained using oral doses which were much lower than tho...

Acute central nervous system (CNS) toxicity and immune-related side effects are increasingly recognized with the use of monoclonal antibodies for cancer therapy. Here, we report a patient who developed of acute-onset encephalopathy and coma, which began shortly after administration of panitumumab for the treatment of metastatic colorectal cancer. Echocardiography revealed that the drug had been...

The development of numerous drugs over the last two decades to a variety of diseases with significant benefits has paralleled increasing awareness of the adverse effects of these drugs. Majority of the drugs are eliminated by the kidneys. Therefore it is mandatory to make appropriate dosage modification when renal function deteriorates to prevent drug toxicity. Dosage modification tables of lar...

The discipline of toxicology considers the adverse effects of chemicals, including drugs, and other agents, such as biological toxins and radiation, on biological systems. Toxicity associated with drug action can generally be characterized as either an extension of the therapeutic effect, such as the fatal central nervous system (CNS) depression that may follow a barbiturate overdose, or as an ...

Despite the introduction in recent years of novel antifungal agents, the potency and broad spectrum of activity of amphotericin B have ensured that it remains the treatment of choice for most deep-seated mycoses. However, this agent is not without significant toxicity, particularly in patients who are already seriously ill and/or who are receiving other potentially nephrotoxic drugs. We review ...

Pulmonary delivery of fluoroquinolones (FQs) is an interesting approach to treat lung infections as it may lead to high local concentrations while minimizing systemic exposure. However, FQs have a rapid diffusion through the lung epithelium giving the pulmonary route no advantage compared to the oral route. Interactions between FQs and metal cations form complexes which limit the diffusion thro...