The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery and the animal were killed 6 h later. The amount of early ischemic damage was assessed in coronal sections at 16 predetermined stereotactic planes. Pretre...

The study attempts to evaluate whether neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) are involved in anxiogenic and anxiolytic reactions induced by NMDA receptor ligands. The animals were given MK-801 (1 mg/kg, ip), a non-competitive NMDA-receptor antagonist, which acts as anxiolytic agent, or NMDA (15 mg/kg, ip), which has an anxiogenic effect. The anxiogenic or anxiolytic acti...

The purpose of this study was to observe the influence of coronal leakage on the behavior of periapical tissues after root canal filling and post space preparation. Forty root canals of dogs' teeth were instrumented and filled by the lateral condensation technique with gutta percha points and the cements Sealer 26 and Roth. After post space preparation, the remaining filling material was either...

NEW IRA DATABASE: The Employee Benefit Research Institute created the EBRI IRA Database in order to more closely examine retirement savings behavior. The EBRI IRA Database is able to link individuals within and across the data providers and will also be able to link the data with participants in 401(k) plans, allowing retirement funds to be tracked as they are generated, rolled over, and ultima...

Focusing information in manufacturing: a knowledge management perspective Ely Laureano Paiva Aleda V. Roth Jaime Evaldo Fensterseifer Article information: To cite this document: Ely Laureano Paiva Aleda V. Roth Jaime Evaldo Fensterseifer, (2002),"Focusing information in manufacturing: a knowledge management perspective", Industrial Management & Data Systems, Vol. 102 Iss 7 pp. 381 389 Permanent...

Facing the global freshwater resource crisis, using solar energy to produce fresh water resources in an environmentally friendly way, sorption-based atmospheric harvesting driven by technology has attracted increasingly more attention. In current research, adsorbent MOF-801 advantages of a high adsorption capacity and is suitable for fields with wide range humidity. However, strong interaction ...

To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx). MK-801 or dantrolene, but not FK506, suppressed convulsive seizures in EL mice; only MK-801 reduced NOx in the brain. Our results suggest...

The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong eviden...