In plants, the ROP family of small GTPases has been implicated in the polarized growth of tip-growing cells, such as root hairs and pollen tubes; however, most of the data derive from overexpressing ROP genes or constitutively active and dominant-negative isoforms, whereas confirmation by using loss-of-function studies has generally been lacking. Here, in the model moss Physcomitrella patens, w...

OBJECTIVE To explore whether early or late and presumed or definite neonatal bacteremia are associated with an increased risk of severe retinopathy of prematurity (ROP). METHODS We evaluated 1059 infants born before week 28 of gestation for ROP. Infants were classified as having early (postnatal week 1) or late (weeks 2-4) definite (culture-proven) or presumed (antibiotics taken for >72 hours...

PURPOSE To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT). METHODS High-speed, high-resolution AO-FDOCT videos were recorded in subjects with a history of ROP (n = 5; age range, 14-26 years) and in control subjects (n = 5; age range, 18-25 years). Custom s...

INTRODUCTION For many decades, researchers worldwide have been investiga­ ting the causes of retinopathy of prematurity (ROP) and the best method to identify the preterm children that are at risk of developing this disease. In 2007, one ROP research group in Brazil published the criteria for se lecting premature children for examination and ROP treatment, following the assessment of regional ch...

Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. With improvement in neonatal care, more preterm infants are surviving with a resultant increase in the number of ROP cases. In low-middle income countries, the disease epidemiology is characterized by the occurrence of ROP at higher birthweight in premature babies with greater severity at...

To the Editors: Retinopathy of prematurity (ROP) remains a major cause of childhood blindness worldwide. The ophthalmologists who provide ROP staging and treatment services face substantial time constraints but still need to provide constructive education and consent information for parents even if they are remote from the neonatal intensive care unit (NICU) at the time of consent for urgent RO...

OBJECTIVE To develop a birth weight (BW), gestational age (GA), and postnatal-weight gain retinopathy of prematurity (ROP) prediction model in a cohort of infants meeting current screening guidelines. METHODS Multivariate logistic regression was applied retrospectively to data from infants born with BW less than 1501 g or GA of 30 weeks or less at a single Philadelphia hospital between Januar...

447 Dear Editor, We would like to report a pilot study to establish the use of smart phone as a diagnostic tool for detecting severe retinopathy of prematurity (ROP) compared to digital wide‐field photographic images. ROP is fast emerging as an important cause of childhood blindness in India.[1‐3] In spite of recommendations for screening of preterm babies to rule out ROP,[4] there is no eviden...

AIMS To study the efficacy of infrared diode laser for the treatment of posterior retinopathy of prematurity (ROP). METHODS 48 eyes of 25 premature babies (mean birth weight 779 (SD 127.7) g; mean gestational age 25.5 (SD 1.47) weeks) with threshold ROP in zone I and posterior zone II were treated by the indirect infrared (810 nm) diode laser. Confluent burns were applied to the avascular ret...

Methods: Digital fundus images were taken of 78 eyes at risk for ROP with a noncontact camera during fundoscopic examination when infants were 31 to 34 weeks of postconception age. Vessel diameters were measured for the major superior and inferior temporal arteries and veins with the use of VesselMap software. Mean vessel diameters from eyes that developed severe ROP requiring treatment were co...