Using a proteomic approach, we searched for protein changes dependent on Rho-associated kinase (ROCK) during phorbol-12-myristate-13-acetate (PMA)-induced apoptosis. We found that heterogeneous nuclear ribonucleoprotein C1 and C2 (hnRNP C1/C2), two nuclear restricted pre-mRNA binding proteins, are translocated to the cytosolic compartment in a ROCK-dependent manner in PMA-induced pro-apoptotic ...

The low molecular weight GTPase Rho mediates a variety of cytoskeleton-dependent cell functions and stretch- and G(q) protein-induced hypertrophic responses in cardiac myocytes. Although ROCK, one of Rho's effectors, has been suggested to mediate hypertrophic signals, the relationship of Rho/ROCK with downstream signals is unknown. A zinc finger transcription factor, GATA-4, is activated by ext...

BACKGROUND Rho and its effector Rho-kinase/ROCK mediate cytoskeletal reorganization as well as smooth muscle contraction. Recent studies indicate that Rho and ROCK are critically involved in vascular remodeling. Here, we tested the hypothesis that Rho/ROCK are critically involved in angiotensin II (Ang II)-induced migration of vascular smooth muscle cells (VSMCs) by mediating a specific signal ...

As known, most important, and the hard part of pattern recognition for rock particles, is image segmentation. Segmentation can be divided into two steps, one is segmentation based on gray levels (called image binarization, sometimes) in which a gray level image is processed and converted into a binary image. Another is segmentation based on rock particle shapes in a binary image, in which overl...

The selectivity of different Rho kinase (ROCK) inhibitors in the spontaneously tonic smooth muscle has not been investigated. We examined this issue using Y-27632 [(R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarbox anecarboxamide, 2HCl], H-1152 [(S)-(+)-(2-methyl-5-isoquinolinyl) sulfonylhomopiperazine, 2HCl], HA-1077 [(5 isoquinolinesulfonyl) homopiperazine, 2HCl], and ROCK inhibit...

The paper presents a new microplane constitutive model for the inelastic behavior of jointed rock masses that takes into account the mechanical behavior and geometric characteristics of cracks and joints. The basic idea is that the microplane modeling of rock masses under general triaxial loading, including compression, requires the isotropic rock matrix and the joints to be considered as two d...

Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date. One of the primary effectors of Rock is non-muscle myosin II. Activation of Rock results in increased contractility of myosin II and subsequent changes in actin architecture and cell morphology. The regulation of R...

This study investigated the effect of the Rho kinase inhibitor Y-27632 and fasudil on the development of human mesangial cell (HMC) inflammation and fibrosis induced by high glucose and to clarify the contribution of the Rho/ROCK signaling pathway in the pathogenesis of diabetic kidney disease (DKD). High glucose (30 mmol/l) induced the Rho/ROCK signaling pathway. Western blotting was used to d...

Original scientific paper Aiming at answering the questions of wear and failure of hob in the rock breaking process, the rock breaking process was simulated in different broken rock conditions by using finite element method. The relationship between normal force, lateral force, rolling force and time was obtained by rock breaking simulation analysis on the single edge disc cutter. The rock stre...

among structured peer-to-peer systems, chord has a general popularity due to its salient features like simplicity, high scalability, small path length with respect to network size, and flexibility on node join and departure. however, chord doesn’t take into account the topology of underlying physical network when a new node is being added to the system, thus resulting in high routing latency an...