BACKGROUND The Rho kinase pathway plays a key role in many early cell/tissue determination events that take place in embryogenesis. Rho and its downstream effector Rho kinase (ROCK) play pivotal roles in cell migration, apoptosis (membrane blebbing), cell proliferation/cell cycle, cell-cell adhesion and gene regulation. We and others have previously demonstrated that inhibition of ROCK blocks e...

Rock bolts ensure structural stability for tunnels and many other underground structures. The pre-load on a rock bolt plays an important role in the structural reinforcement and it is vital to monitor the pre-load status of rock bolts. In this paper, a rock bolt pre-load monitoring method based on the piezoceramic enabled time reversal method is proposed. A lead zirconate titanate (PZT) patch t...

Com mercial stat ic strain indicators and signal conditioners vary considerably in their circuit details; and, although most of them are based upon some form of the Wheatstone bridge circuit, the bridge circuit is employed in differing ways in different instruments. Because of the many variations in instrument design, a completely general treatment of instrument nonlinearities is not practicabl...

OBJECTIVE It has been reported that leukocyte ROCK activity is elevated in patients after ischemic stroke, but it is unclear whether leukocyte ROCK activity is associated with clinical outcomes following acute stroke events. The objective of this study is to investigate if leukocyte ROCK activity can predict the outcomes in patients with acute ischemic stroke. MATERIALS AND METHODS We enrolle...

The paper presents summary of the work carried out by the author on the modelling of jointed rock mass with some field applications. The equivalent continuum analyses approach presented attempts to use statistical relations, which are simple and obtained after analyzing a large data from the literature on laboratory test results of jointed rock masses. Systematic investigations were done includ...

The prediction of rock mass behavior is an important task in many engineering projects, as the behavior of rock masses can be controlled by the presence of discontinuities. Being able to map the structure of a rock mass is crucial to understanding its potential behavior. This understanding can positively impact the safety and efficiency of an engineering project. In this research, rock masses w...

Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2, and they have different functions in several vascular components. The Ras homolog gene family member A/ROCK pathway plays an important role in various fundamental cellular functions, including contraction, motility, proliferatio...

The Imager for Mars Pathfinder (IMP) was a mast-mounted instrument on the Mars Pathfinder lander which landed on Mars’ Ares Vallis floodplain on July 4, 1997. During the 83 sols of Mars Pathfinders landed operations, the IMP collected over 16,600 images. Multispectral images were collected using twelve narrowband filters at wavelengths between 400 and 1000 nm in the visible and near infrared (V...

1.INTRODUCTION Some forty years ago, most opening supports and reinforcements were designed using empirical rules defining ground loads acting on the supporting structures. This approach is still popular and interest in it has been renewed by the use of rock mass classification systems (Barton et al. 1974, Bieniawski, 1974,1976,1989). Correlations between rock mass conditions and the type of su...