Romantic relationship satisfaction (RRS) is important for mental/physical health but varies greatly across individuals. To date, we have known little about the biological (genetic and neural) correlates of RRS. We tested the hypothesis that the serotonin transporter promoter polymorphism (5-HTTLPR), the promoter region of the gene SLC6A4 that codes for the serotonin transporter protein, is asso...

Repetitive negative thinking (RNT) is a transdiagnostic process involved in the risk, maintenance, and relapse of serious conditions including mood disorders, anxiety, eating disorders, and addictions. Processing mode theory provides a theoretical model to assess, research, and treat RNT using a transdiagnostic approach. Clinical researchers also often employ categorical approaches to RNT, incl...

Background: Osteoarthritis (OA) is the leading cause of chronic disability worldwide, affecting 12% population, and yet we still do not have a disease-modifying treatment. Cartilage breakdown hallmark OA, patients suffer from pain loss joint function/independence, severely quality life. Therefore, there huge unmet clinical need. Receptor tyrosine kinase–like orphan receptor 2 (ROR2) non-canonic...

The lack of clarity of the cytological representations of non-nuclear structures appearing in figures which accompany various papers describing the sporulation process has always left the author somewhat dissatisfied. Nuclear elements typically are distinctly stained while the cytoplasm and cell walls usually are either indistinguishable or very faintly discernible. The techniques which have be...

reasons to fit hearing aids bilaterally: better sound localization and better speech understanding in background noise. To be sure, some elderly persons may do better when fitted monaurally, perhaps due to an age-related interaural interference effect, but these two principal advantages of bilateral fittings have been demonstrated many times over in the majority of hearing aid users. In this is...

Vesicle-mediated protein transport between organelles of the secretory and endocytic pathways is strongly influenced by the composition and organization of membrane lipids. In budding yeast, protein transport between the trans-Golgi network (TGN) and early endosome (EE) requires Drs2, a phospholipid translocase in the type IV P-type ATPase family. However, downstream effectors of Drs2 and speci...

Since hypophosphatasia was first described (Rathbun, 1948), other cases which have been recognized have raised the possibility that this defect of alkaline phosphatase is an inherited inborn error of metabolism. Schneider and Corcoran (1950) first suggested that this was an inherited disorder when two cases were found in one family, and this was corroborated by Sobel, Clark, Fox and Robinow (19...